Section 1: Process Design and Product Quality Attributes<br>1. Physicochemical Principles Governing Agglomeration and Growth Kinetics<br>2. Microstructure and Mechanical Properties of Granules Formed in High Shear Wet Granulation<br>3. Mechanistic Basis for the Effects of Process Parameters on Quality Attributes in High Shear Wet Granulation<br>4. Structures and Properties of Granules Prepared By High Shear Wet Granulation<br>5. Wet Granulation and Chemical Stability of Drug Products<br>6. Material Physical Modifications Induced by Wet Granulation (Current chapter 6)<br>7. Current Practices in Wet Granulation-Based Generic Product Development<br>Section 2: Excipients and Input Material Attributes<br>8. Material Attributes and Their Impact on Wet Granulation Process Performance<br>9. Binders in Wet Granulation<br>10. Effect of Binder Attributes on Granule Growth and Densification<br>11. Role of Drug Substance Material Properties in the Processibility and Performance of Wet Granulated Products<br>12. Critical Material Attributes in Wet Granulation<br>13. Critical material attributes during continuous twin-screw wet granulation<br>Section 3: PAT, Scale-up, Control Strategy<br>14. Inline Focused Beam Reflectance Measurement During Wet Granulation<br>15. Principles and Applications of Drag Force Flow Sensor<br>16. An Introduction to Powder Characterization<br>17. A Quality By Design Approach to Scale-Up of High Shear Wet Granulation Process<br>18. Integrated Application of Quality-by-Design Principles to Drug Product and Its Control Strategy Development<br>19. Implementation of Pharmaceutical Quality by Design in Wet Granulation<br>Section 4: Process Modeling and Emerging Trends<br>20. Numerical Modeling for Wet Granulation Processes<br>21. Application of the Discrete Element Method to Scale-Up of High-Shear Granulation<br>22. Advances in Computational Modelling and Simulation of Wet Granulation Processes <br>23. Twin Screw Continuous Wet Granulation<br>24. Melt granulation: Granulation mechanisms, Formulation and process design for batch and twin-screw systems<br>25. The application of the state-of-art material library/material database approach to the process understanding and process modeling of wet granulation<br>26. Emerging Paradigms in Pharmaceutical Wet Granulation
