Essentials of Pharmatoxicology in Drug Research, Volume 1

1. Understanding Pharmacotoxicology<br>2. Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development<br>3. Omics in Mechanistic and Predictive Toxicology<br>4. Role of Micro RNAs in Toxicology<br>5. Exosomes as Mediators of Chemical-Induced Toxicity<br>6. Types of Cellular Responses to Chemical Toxicants<br>7. Tissue Repair as A Key Determinant in Toxicant-Induced Injury<br>8. Role Of “Toxicant-Induced Loss of Tolerance” in the Emergence of Disease<br>9. Computer-Aided Technologies in Drug Discovery and Toxicity Prediction<br>10. Adverse Outcome Pathway for Chemical Toxicity<br>11. Toxicokinetics and Organ-Specific Toxicity<br>12. Dose Selection for Toxicity Studies<br>13. Tissue-Based Models as A Replacement for Animal Models in Toxicity Testing<br>14. Medication Error and its Toxicity Connection<br>15. Idiosyncratic Toxicity<br>16. Toxicological Risk Assessment<br>17. Clinical Detoxification of the Body<br>18. Principles of Management of Acute Poisoning<br>19. Predicting Toxicity and Modes of Toxic Action from Chemical Structure<br>20. Toxicity Labels<br>21. Toxic Potential Indicator<br>22. Aquatic Toxicology<br>23. Concept of Pharmacotherapy and Managed Care in Clinical Interventions<br>24. Psychopharmacology in Late Life: Key Challenges and Opportunities<br>25. Regulatory Agencies for Toxicity Studies<br>26. Key Challenges for Toxicologists in the 21st Century