Molecular Reviews in Cardiovascular Medicine

Basic methodology in the molecular characterization of genes. Genetic linkage analysis in hypertension: principles and practice. Molecular biology of renin. Discovery of genes for essential hypertension. Molecular regulation of smooth muscle contraction. Molecular biology of adrenergic receptors. Transgenic rates in hypertension research. Cloning, expression and regulation of angiotensin II receptors. Molecular biology and biochemistry of the natriuretic peptide system. Molecular regulation of plasma and tissue angiotensinogen. Molecular biology of oncogenes and cardiovascular hypertrophy. Molecular and cellular biology of endothelin and its receptors. Finding genes that cause human hypertension. Methods for the reduction or ablation of gene function. Molecular biology of the angiotensin I converting enzyme. The molecular biology of the kallikrein-kinin system. Prostaglandins and their receptors. The role of apolipoproteins in lipid metabolism and atherogenesis: aspects in man and mice. Vasopressin in the regulation of body functions. Beyond genetic markers: hypertension genes. Molecular aspects of signal transduction of shear stress in the endothelial cell. Index.