Principles of Clinical Cancer Genetics
A Handbook from the Massachusetts General Hospital
Samenvatting
Advances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed.
In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.
Specificaties
Inhoudsopgave
Principles of Cancer Genetic Counseling and Genetic Testing
Genetics of Hereditary Breast Cancer
Surgical management of Hereditary Breast and Ovarian Cancer
Hereditary colon cancer: Colonic Polyposis Syndromes
Hereditary colon cancer: Lynch Syndrome
Hereditary Pancreatic Cancer
Hereditary Diffuse Gastric Cancer
Familial Renal Cell Cancers and Pheochromocytomas
Familial Atypical Mole Melanoma (FAMM) Syndrome
Multiple Endocrine Neoplasia
Pediatric malignancies: Retinoblastoma and Wilms’ tumor
Neurofibromatosis and Schwannomatosis
The Hap Map project and low penetrance cancer susceptibility alleles
Somatic genetic alterations and implications for targeted therapies in cancer (GIST, CML, Lung cancer)