Bani Bandana Ganguly
Elsevier Science
e druk, 2022
9780323904568
Genetics and Neurobiology of Down Syndrome
Specificaties
Paperback, blz.
|
Engels
Elsevier Science |
e druk, 2022
ISBN13: 9780323904568
Rubricering
Levertijd ongeveer 8 werkdagen
Samenvatting
Genetics and Neurobiology of Down Syndrome provides a thorough review of the genetic etiology and mechanisms of trisomy 21. The author discusses the history of the syndrome, along with the clinical features and health consequences, including physical features, cognitive, and neurologic symptoms. Genetic counseling on pros and cons of prenatal screening and testing and associated ethical issues are explored. This unique book also covers the societal and demographic aspects as well as the future direction of therapeutic development.
Specificaties
Inhoudsopgave
<p>Overview<br>Bani Ganguly<br>Preface<br>Bani Ganguly<br>1. History and Overview of Down Syndrome: Then and Now<br>Bani Ganguly and Nitin Kadam<br>2. Congenital features and health aspects in Down syndrome<br>Bani Ganguly and Nitin Kadam<br>3. Chromosomal cause of Down syndrome<br>Bani Ganguly<br>4. Possible Causes of Chromosomal Non-Disjunction<br>Bani Ganguly<br>5. Prevention: Prenatal Screening, Testing and Genetic Counseling, and Socio-cultural Aspects of Down Syndrome<br>Bani Ganguly<br>6. Gene-dosage imbalance of trisomic HSA21 and Genotype-phenotype association in Down syndrome <br>Bani Ganguly<br>7. Development of specific phenotypes and genetic consequences in Down syndrome: malformations in craniofacial and cardiac anatomy, and development of leukemia and cognitive and learning deficits<br>Bani Ganguly<br>8. Mitochondrial dysfunction in Down syndrome<br>Bani Ganguly<br>9. Mitochondrial abnormalities on patho-biology in Down syndrome<br>Bani Ganguly<br>10. Neurogenesis and genetic consequences in Down syndrome<br>Bani Ganguly<br>11. Glutamatergic and GABAergic mechanisms and therapeutic targets in Down Syndrome<br>Bani Ganguly<br>12. Alzheimer Disease in Down syndrome (DSAD)<br>Bani Ganguly<br>13. MicroRNAs and epigenetic signatures in Down syndrome <br>Bani Ganguly<br>14. In vivo and in vitro models for research on Down syndrome <br>Bani Ganguly</p>