Adam Eltorai,
Anthony Atala,
Ali Arab,
Mohummad Minhaj Siddiqui,
Adam E.M. Eltorai
e.a.
Elsevier Science
e druk, 2024
9780323901864
Translational Urology
Specificaties
Paperback, blz.
|
Engels
Elsevier Science |
e druk, 2024
ISBN13: 9780323901864
Rubricering
Onderdeel van serie
Handbook for Designing and Conducting Clinical and Translational Research
Levertijd ongeveer 8 werkdagen
Samenvatting
Translational Urology covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. The reader will come to fully understand important concepts, including case-control study, prospective cohort study, randomized trial, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in urology, and know what is needed for successful collaboration. Further, this title is an indispensable tool in grant writing and funding efforts.
This practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in urology, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care.
Specificaties
Inhoudsopgave
INTRODUCTION<br>1. Introduction<br>2. Translational Process<br>3. Scientific Method<br>4. Basic Research<br><br>PRE-CLINCIAL<br>5. Overview of Preclinical Research<br>6. What Problem are you Solving?<br>7. Types of Interventions<br>8. Drug discovery<br>9. Drug Testing<br>10. Device Discovery and Prototyping<br>11. Device testing<br>12. Other product types<br>13. Procedural Technique Development<br>14. Behavioral Intervention<br><br>CLINICAL: FUNDAMENTALS<br>15. Introduction to clinical research: What is it? Why is it needed?<br>16. Study population: Who and why them?<br>17. Outcome measurements: What data is being collected and why?<br><br>TATISTICAL PRINCIPLES<br>18. Common issues in analysis<br>19. Basic statistical principles<br>20. Distributions<br>21. Hypotheses and error types<br>22. Power<br>23. Regression<br>24. Continuous Variable Analyses: Student’s t-test, Rank-Sum Test, and Signed-Rank Test<br>25. Categorical variable analyses: Chi-square, fisher exact, Mantel hanzel<br>26. Analysis of variance<br>27. Correlation<br>28. Basic science statistics<br><br>CLINICAL: STUDY TYPES<br>29. Design principles: Hierarchy of study types<br>30. Case series: Design, measures, classic example<br>31. Case-control study: Design, measures, classic example<br>32. Cohort study: Design, measures, classic example<br>33. Cross-section study: Design, measures, classic example<br>34. Longitudinal Study: Design, measures, classic example<br>35. Clinical trials: Design, measures, classic example<br>36. Meta-analysis: Design, measures, classic example<br>37. Cost-Effectiveness Analysis: Design, Measures, and Classic Example<br>38. Database Research in Urology<br>39. Surveys and questionnaires: Design, measures, classic example<br>40. Qualitative methods and mixed methods<br><br>CLINICAL TRIALS<br>41. Randomized Controlled Trials: Design, Measures, and Classic Examples<br>42. Nonrandomized control: Design, measures, classic example<br>43. Historical control: Design, measures, classic example<br>44. Cross-over: Design, measures, classic example<br>45. Withdrawal Studies<br>46. Equivalence and noninferiority: Design, measures, classic example<br>47. Randomization: Fixed or adaptive procedures<br>48. Blinding: Who and how?<br>49. Multicenter considerations<br>50. Phases of Clinical Trials<br>51. Window of Opportunity, Phase 0 Trials<br>52. IDEAL Framework<br>53. Artificial Intelligence<br>54. Patient Perspectives<br><br>CLINICAL: PREPARATION<br>55. Sample Size<br>56. Budgeting<br>57. Ethics and review boards<br>58. Regulatory considerations for new drugs and devices<br>59. Funding approaches<br>60. Data management<br>61. Statistical Software<br>62. Subject adherence<br>63. Survival analysis<br>64. Monitoring committee in clinical trials<br><br>REGULATORY BASICS<br>65. FDA overview<br>66. IND<br>67. New drug application<br>68. Devices<br>69. Biologics<br>70. Combination Products<br>71. Foods<br>72. CMC and GxP<br>73. Post-Market Drug Safety Monitoring<br>74. Post-Market Device Safety Monitoring<br><br>CLINICAL IMPLEMENTATION<br>75. Implementation Research<br>76. Design and Analysis<br>77. Population- and Setting-Specific Implementation<br><br>PUBLIC HEALTH<br>78. Public Health<br>79. Epidemiology<br>80. Public Health Factors and Social Determinants of Health in Urological Research<br>81. Good Questions<br>82. Population- and Environmental-Specific Considerations<br>83. Healthcare Institutions and Systems<br>84. Public Health Institutions and Systems<br><br>Practical Resources<br>85. Presenting Data<br>86. Manuscript Preparation<br>87. Building a Team<br>88. Patent Basics<br>89. Venture Pathways<br>90. SBIR/STTR<br>91. Sample Forms and Templates