Essential Tremor: Current Concepts and Controversies

<p>1. What’s in a name? nomenclature of essential tremor- syndrome or family of diseases?<br>Louis & Kuo<br>Is essential tremor a family of diseases or a syndrome? A family of diseases<br>Riboldi & Frucht<br>Is essential tremor a family of diseases or a syndrome? A syndrome<br>Pandey </p> <p>2. Essential tremor- Is this an electrical or a degenerative disorder? Or is it both?<br>Louis & Kuo<br>Is essential tremor a degenerative disorder or an electric disorder? A degenerative disorder<br>Faust<br>Is essential tremor a degenerative disorder or an electric disorder? An electric disorder<br>Cho</p> <p>3. How important is the inferior olive in essential tremor? An evolving story<br>Kuo & Louis<br>Is inferior olive central to the pathophysiology of essential tremor? Yes<br>Lang & Handforth<br>Is inferior olive central to the pathophysiology of essential tremor? No<br>Manto</p> <p>4. Essential tremor as a harbinger- what is the cognitive fallout of having essential tremor?<br>Louis & Kuo<br>Does essential tremor increase the risk of dementia? Yes<br>Cosentino & Shih<br>Does essential tremor increase the risk of dementia? No<br>Rajput</p> <p>5. Is essential tremor a disorder primarily due to GABA dysfunction?<br>Kuo & Louis<br>Is essential tremor a disorder of primary GABA dysfunction? Yes<br>Gironell<br>Is essential tremor a disorder of primary GABA dysfunction? No<br>Bellows &Jimenez-Shahed</p> <p>6. The future of pharmacotherapies for essential tremor: enhancing GABA neurotransmission or reducing neuronal hyper-excitability?<br>Kuo & Louis<br>What is the next generation of medication for essential tremor? Enhancing GABAergic inhibition<br>Ondo<br>What is the next generation of medication for essential tremor? Reduction of hyper-excitability<br>Shukla</p>