<p>SECTION 1: REACTIVE NONSPECIFIC CHANGES</p> <p>4 Reactive Follicular Hyperplasia</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>10 Reactive Paracortical Hyperplasia</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>SECTION 2: INFECTIOUS CAUSES OF LYMPHADENITIS</p> <p>20 Chronic Granulomatous Lymphadenitis</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>28 Suppurative Lymphadenitis</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>32 Mycobacterium tuberculosis Lymphadenitis</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>40 Atypical Mycobacterial Lymphadenitis</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>48 Mycobacterial Spindle Cell Pseudotumor</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>52 Cat-Scratch Disease</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>58 Bacillary Angiomatosis</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>64 Lymphogranuloma Venereum Lymphadenitis</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>68 Whipple Disease</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>72 Syphilitic Lymphadenitis</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>78 Infectious Mononucleosis</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>84 Histoplasma Lymphadenitis</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>90 Cryptococcus Lymphadenitis</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>94 Toxoplasma Lymphadenitis</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>100 Coccidioides Lymphadenitis</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>106 Herpes Simplex Lymphadenitis</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>112 Cytomegalovirus Lymphadenitis</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>120 Human Immunodeficiency Virus Lymphadenitis</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>SECTION 3: REACTIVE LYMPHADENOPATHIES</p> <p>132 Inflammatory Pseudotumor of Lymph Node</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>140 Progressive Transformation of Germinal Centers</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>146 Kikuchi-Fujimoto Disease</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>156 Rosai-Dorfman Disease</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>166 Kimura Disease</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>174 Unicentric Hyaline-Vascular Variant Castleman Disease</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>182 Unicentric Mixed/Plasmacytic Variant Castleman Disease</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>188 Multicentric Castleman Disease, Idiopathic</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>196 Multicentric Castleman Disease, HHV8 Associated</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>204 Rheumatoid Arthritis-Related Lymphadenopathy</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>212 Sarcoid Lymphadenopathy</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>218 Dermatopathic Lymphadenopathy</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>224 Hemophagocytic Lymphohistiocytosis</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>234 Lymphadenopathy Associated With Joint Prostheses</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>240 Lipid-Associated Lymphadenopathy</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>244 Lymphadenopathy Secondary to Drug-Induced Hypersensitivity Syndrome</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>254 IgG4-Related Disease</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>264 Systemic Lupus Erythematosus</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>270 Sinus Histiocytosis</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>SECTION 4: HODGKIN LYMPHOMAS</p> <p>278 Nodular Lymphocyte-Predominant Hodgkin Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD<br>290 Nodular Lymphocyte-Predominant Hodgkin Lymphoma: Tables</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>292 Lymphocyte-Rich Classic Hodgkin Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>300 Nodular Sclerosis Hodgkin Lymphoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>310 Mixed Cellularity Hodgkin Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>316 Lymphocyte-Depleted Hodgkin Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>SECTION 5: LEUKEMIA/LYMPHOMAS OF IMMATURE B- OR T-CELL LINEAGE</p> <p>324 B-Lymphoblastic Leukemia/Lymphoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>334 T-Lymphoblastic Lymphoma/Leukemia</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>SECTION 6: NODAL B-CELL LYMPHOMAS</p> <p>346 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>356 Richter Transformation</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>364 Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>374 Nodal Marginal Zone Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>380 Nodal Follicular Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>392 Pediatric-Type Follicular Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>396 Mantle Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>404 Mantle Cell Lymphoma, Blastoid and Pleomorphic Variants</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>412 Diffuse Large B-Cell Lymphoma, Not Otherwise Specified</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>422 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>428 ALK(+) Large B-Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>434 EBV(+) Diffuse Large B-Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>442 HHV8(+) Diffuse Large B-Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>450 Burkitt Lymphoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>460 High-Grade B-Cell Lymphoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>468 Mediastinal Gray Zone Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>SECTION 7: EXTRANODAL B-CELL LYMPHOMAS</p> <p>480 Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma)</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>494 Extranodal Follicular Lymphoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>506 Primary Cutaneous Follicle Center Lymphoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>516 Primary Mediastinal (Thymic) Large B-Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>526 Primary Diffuse Large B-Cell Lymphoma of Central Nervous System</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>536 Pyothorax-Associated Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>542 Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>550 Plasmablastic Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>560 Primary Effusion Lymphoma and Solid Variant of Primary Effusion Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>570 Lymphomatoid Granulomatosis</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>580 Intravascular Large B-Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>586 Plasmacytoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>594 EBV-Positive Large B-Cell Lymphoma Associated With Breast Implants</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>600 Primary Diffuse Large B-Cell Lymphoma of Testis</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>608 Splenic Marginal Zone Lymphoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>616 Hairy Cell Leukemia</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>624 Hairy Cell Leukemia Variant</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>632 Splenic Diffuse Red Pulp B-Cell Lymphoma</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>638 Diffuse Large B-Cell Lymphoma Arising in the Spleen</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>SECTION 8: NODAL T-CELL LYMPHOMAS</p> <p>646 Peripheral T-Cell Lymphoma, Not Otherwise Specified</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>656 Angioimmunoblastic T-Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>666 Adult T-Cell Leukemia/Lymphoma, HTLV-1(+)</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>676 ALK(+) Anaplastic Large Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>684 ALK(-) Anaplastic Large Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>SECTION 9: EXTRANODAL NK-/T-CELL LYMPHOMAS</p> <p>694 Breast Implant-Associated Anaplastic Large Cell Lymphoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>706 Extranodal NK-/T-Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>716 Hepatosplenic T-Cell Lymphoma</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>726 Enteropathy-Associated T-Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>734 Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>742 Indolent T-Cell Lymphoma of the Gastrointestinal Tract</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>748 Subcutaneous Panniculitis-Like T-Cell Lymphoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>756 T-Cell Prolymphocytic Leukemia Involving Lymph</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>766 Primary Cutaneous γ/δ T-Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>774 EBV(+) T- and NK-Cell Lymphoid Proliferations and Lymphomas of Childhood</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>784 Mycosis Fungoides</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>798 Sézary Syndrome</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>810 Primary Cutaneous Anaplastic Large Cell Lymphoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>818 Lymphomatoid Papulosis</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>826 Primary Cutaneous Acral CD8(+) Lymphoproliferative Disorder</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>832 Primary Cutaneous CD8(+) Aggressive</p> <p>Epidermotropic Cytotoxic T-Cell Lymphoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>840 Primary Cutaneous CD4(+) Small/Medium T-Cell Lymphoproliferative Disorder</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>SECTION 10: IMMUNODEFICIENCYASSOCIATED LYMPHOPROLIFERATIONS</p> <p>846 Overview of Primary Immunodeficiency-Associated Lymphoproliferative Disorders</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>852 Autoimmune Lymphoproliferative Syndrome</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>864 Immunomodulating Agent-Associated Lymphoproliferative Disorders</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>872 Posttransplant Lymphoproliferative Disorders, Nondestructive Lesions and Polymorphic</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>882 Posttransplant Lymphoproliferative Disorder, Monomorphic</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>892 EBV(+) Mucocutaneous Ulcer</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>SECTION 11: GRANULOCYTIC/HISTIOCYTIC TUMORS</p> <p>898 Myeloid Sarcoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>906 Blastic Plasmacytoid Dendritic Cell Neoplasm</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>914 Blastic T/Myeloid Neoplasm With Rearrangements of FGFR1</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>924 Cutaneous Mastocytosis</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>928 Systemic Mastocytosis</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>940 Histiocytic Sarcoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>950 Follicular Dendritic Cell Sarcoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>958 Interdigitating Dendritic Cell Sarcoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>964 Langerhans Cell Histiocytosis</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>976 Langerhans Cell Sarcoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>984 Erdheim-Chester Disease</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>SECTION 12: NONHEMATOPOIETIC PROLIFERATIONS IN LYMPH NODE</p> <p>990 Epithelial Inclusions in Lymph Node</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>996 Nevus Cell Inclusions in Lymph Node</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>1000 Vascular Transformation of Lymph Node Sinuses</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>1004 Angiomyomatous Hamartoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>1008 Palisaded Myofibroblastoma</p> <p>L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD</p> <p>1012 Metastatic Kaposi Sarcoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p>