<p>SECTION 1: THYROID NONNEOPLASTIC HEREDITARY/GENETIC/CONGENITAL<br>4 Thyroglossal Duct Cyst<br>Vania Nosé, MD, PhD and Nicole A. Cipriani, MD<br>8 Ectopic Thyroid<br>Vania Nosé, MD, PhD<br>12 Solid Cell Nests<br>Vania Nosé, MD, PhD<br>16 Dyshormonogenetic Goiter<br>Vania Nosé, MD, PhD<br><br>INFECTIOUS<br>22 Acute Thyroiditis<br>Vania Nosé, MD, PhD<br><br>AUTOIMMUNE/INFLAMMATORY<br>26 Subacute/Granulomatous Thyroiditis<br>Vania Nosé, MD, PhD<br>32 Palpation Thyroiditis<br>Vania Nosé, MD, PhD and Nicole A. Cipriani, MD<br>34 IgG4-Related Thyroid Disease<br>Vania Nosé, MD, PhD<br>38 Riedel Thyroiditis<br>Vania Nosé, MD, PhD<br>44 Hashimoto Thyroiditis<br>Vania Nosé, MD, PhD<br>52 Graves Disease (Diffuse Hyperplasia)<br>Suzana Leite, MD and Vania Nosé, MD, PhD<br>60 Amyloid Goiter<br>Vania Nosé, MD, PhD<br><br>REACTIVE<br>66 Pigments and Crystals, Thyroid<br>Nicole A. Cipriani, MD and Vania Nosé, MD, PhD<br>72 Post-FNA Site Changes, Thyroid<br>Vania Nosé, MD, PhD and Darcy A. Kerr, MD<br><br>NEOPLASTIC FOLLICULAR CELL-DERIVED NEOPLASMS<br>74 Thyroid Follicular Nodular Disease<br>Vania Nosé, MD, PhD<br>80 Adenomatous Nodules<br>Vania Nosé, MD, PhD and Lori A. Erickson, MD<br>86 Follicular Thyroid Adenoma<br>Vania Nosé, MD, PhD and Lori A. Erickson, MD<br>94 Follicular Thyroid Adenoma With Papillary <br>Architecture <br>Vania Nosé, MD, PhD <br>98 Oncocytic Thyroid Adenoma <br>Vania Nosé, MD, PhD and Lori A. Erickson, MD <br>102 Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features<br>Vania Nosé, MD, PhD and Ying-Hsia Chu, MD<br>112 Hyalinizing Trabecular Tumor of Thyroid<br>Vania Nosé, MD, PhD and Nicole A. Cipriani, MD<br>118 Follicular Thyroid Carcinoma<br>Vania Nosé, MD, PhD and Lori A. Erickson, MD<br>128 Oncocytic Thyroid Carcinoma<br>Ying-Hsia Chu, MD and Vania Nosé, MD, PhD<br>132 Invasive Encapsulated Follicular Variant Papillary Thyroid Carcinoma<br>Vania Nosé, MD, PhD and Lori A. Erickson, MD<br>140 Kinase Fusion-Related Thyroid Carcinomas<br>Ying-Hsia Chu, MD and Vania Nosé, MD, PhD<br>148 Follicular Cell-Derived Thyroid Carcinoma, High Grade<br>Nicole A. Cipriani, MD and Vania Nosé, MD, PhD<br>158 Anaplastic Thyroid Carcinoma<br>Vania Nosé, MD, PhD and Lori A. Erickson, MD<br>168 Papillary Thyroid Carcinoma<br>Vania Nosé, MD, PhD and Ying-Hsia Chu, MD<br>182 Classic Papillary Thyroid Carcinoma<br>Vania Nosé, MD, PhD and Julie Guilmette, MD, FRCPC<br>190 Infiltrative Follicular Variant Papillary Thyroid Carcinoma<br>Vania Nosé, MD, PhD and Lori A. Erickson, MD<br>194 Macrofollicular Papillary Thyroid Carcinoma<br>Vania Nosé, MD, PhD<br>200 Diffuse Sclerosing Papillary Thyroid Carcinoma<br>Nicole A. Cipriani, MD and Vania Nosé, MD, PhD<br>206 Oncocytic Papillary Thyroid Carcinoma<br>Vania Nosé, MD, PhD and Peter M. Sadow, MD, PhD<br>210 Tall Cell Papillary Thyroid Carcinoma<br>Vania Nosé, MD, PhD and Julie Guilmette, MD, FRCPC<br>218 Columnar Cell Papillary Thyroid Carcinoma<br>Vania Nosé, MD, PhD and Lori A. Erickson, MD<br>222 Clear Cell Papillary Thyroid Carcinoma<br>Vania Nosé, MD, PhD and Julie Guilmette, MD, FRCPC<br>224 Solid/Trabecular Papillary Thyroid Carcinoma<br>Vania Nosé, MD, PhD and Julie Guilmette, MD, FRCPC<br>228 Hobnail Papillary Thyroid Carcinoma<br>Julie Guilmette, MD, FRCPC and Vania Nosé, MD, PhD<br>234 Warthin-Like Papillary Thyroid Carcinoma<br>Vania Nosé, MD, PhD<br><br>C-CELL-DERIVED TUMORS<br>240 C-Cell Hyperplasia<br>Vania Nosé, MD, PhD and Adam S. Fisch, MD, PhD<br>246 Medullary Thyroid Carcinoma<br>Vania Nosé, MD, PhD and Adam S. Fisch, MD, PhD<br><br>MIXED MEDULLARY AND FOLLICULAR CELL CARCINOMA<br>256 Mixed Medullary and Follicular Cell-Derived Thyroid Carcinoma<br>Vania Nosé, MD, PhD and Darcy A. Kerr, MD<br><br>THYMIC TUMORS WITHIN THYROID<br>260 Spindle Epithelial Tumor With Thymus-Like Differentiation<br>Vania Nosé, MD, PhD<br>266 Intrathyroid Thymic Carcinoma<br>Vania Nosé, MD, PhD<br><br>SALIVARY GLAND-LIKE THYROID TUMORS<br>274 Mucoepidermoid Carcinoma of Thyroid<br>Darcy A. Kerr, MD and Vania Nosé, MD, PhD<br>278 Secretory Carcinoma of Salivary Gland Type<br>Darcy A. Kerr, MD and Vania Nosé, MD, PhD<br><br>HEMATOLYMPHOID TUMORS<br>282 Lymphoma, Thyroid<br>Judith Ferry, MD<br>288 Follicular Dendritic Cell Sarcoma, Thyroid<br>Vania Nosé, MD, PhD and Darcy A. Kerr, MD<br>292 Langerhans Cell Histiocytosis, Thyroid<br>Vania Nosé, MD, PhD and Dipti P. Sajed, MD, PhD<br><br>GERM CELL ORIGIN<br>296 Benign Thyroid Teratoma<br>Vania Nosé, MD, PhD<br>302 Struma Ovarii, Struma Carcinoid, and Malignant Struma Ovarii<br>Vania Nosé, MD, PhD<br><br>EMBRYONAL THYROID TUMORS<br>310 Thyroblastoma<br>Vania Nosé, MD, PhD and Julie Guilmette, MD, FRCPC<br><br>MESENCHYMAL AND STROMAL TUMORS<br>316 Peripheral Nerve Sheath Tumor, Thyroid<br>Vania Nosé, MD, PhD and Darcy A. Kerr, MD<br>320 Solitary Fibrous Tumor, Thyroid<br>Dipti P. Sajed, MD, PhD and Vania Nosé, MD, PhD<br>326 Paraganglioma, Thyroid<br>Lori A. Erickson, MD and Vania Nosé, MD, PhD<br>332 Leiomyoma and Leiomyosarcoma, Thyroid<br>Dipti P. Sajed, MD, PhD and Vania Nosé, MD, PhD<br>336 Angiosarcoma, Thyroid<br>Dipti P. Sajed, MD, PhD and Vania Nosé, MD, PhD<br>340 Primary Ewing Sarcoma, Thyroid<br>Dipti P. Sajed, MD, PhD and Vania Nosé, MD, PhD<br><br>SECONDARY TUMORS WITHIN THYROID<br>344 Metastasis to Thyroid Gland<br>Vania Nosé, MD, PhD and Darcy A. Kerr, MD<br><br>TUMORS OF UNCERTAIN HISTOGENESIS<br>350 Cribriform Morular Thyroid Carcinoma<br>Vania Nosé, MD, PhD<br>360 Sclerosing Mucoepidermoid Carcinoma With Eosinophilia<br>Darcy A. Kerr, MD and Vania Nosé, MD, PhD<br><br>MOLECULAR PATHOLOGY OF THYROID NEOPLASMS<br>366 Molecular Pathology of Thyroid Neoplasms<br>Vania Nosé, MD, PhD and Ying-Hsia Chu, MD<br><br>PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF THYROID GLAND<br>372 Thyroid Carcinoma Protocol<br>Vania Nosé, MD, PhD and Julie Guilmette, MD, FRCPC<br><br>SECTION 2: PARATHYROID GLAND NONNEOPLASTIC<br>376 Primary Multiglandular Parathyroid Disease<br>Lori A. Erickson, MD<br>386 Primary Parathyroid Clear Cell Hyperplasia<br>Lori A. Erickson, MD<br>390 Secondary Parathyroid Hyperplasia<br>Lori A. Erickson, MD<br>396 Tertiary Parathyroid Hyperplasia<br>Lori A. Erickson, MD<br>400 Chronic Parathyroiditis<br>Lori A. Erickson, MD<br><br>NEOPLASTIC<br>404 Parathyroid Adenoma<br>Lori A. Erickson, MD and Vania Nosé, MD, PhD<br>412 Parathyroid Lipoadenoma<br>Lori A. Erickson, MD<br>416 Atypical Parathyroid Tumor<br>Vania Nosé, MD, PhD and Lori A. Erickson, MD<br>422 Parathyroid Carcinoma<br>Vania Nosé, MD, PhD and Lori A. Erickson, MD<br>432 Metastasis to Parathyroid Gland<br>Lori A. Erickson, MD<br><br>SECTION 3: ADRENAL GLANDS ADRENAL CORTICAL NONNEOPLASTIC<br>438 Adrenal Heterotopia<br>Arthur S. Tischler, MD<br>440 Adrenal Hypoplasia and Malformations<br>Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD<br>444 Adrenal Cytomegaly<br>Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD<br>446 Infectious Disorders, Adrenal Glands<br>Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH<br>450 Autoimmune Adrenalitis<br>Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH<br>452 Adrenal Amyloidosis<br>Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH<br>456 Incidental Adrenal Nodules<br>Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD<br>460 Adrenal Cysts<br>Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD<br><br>ADRENAL CORTICAL NEOPLASTIC<br>466 Adrenocortical Hyperplasia and Adrenocortical Nodular Disease<br>Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD<br>472 Primary Pigmented Nodular Adrenocortical Disease<br>Vania Nosé, MD, PhD<br>478 Nonfunctioning Adrenal Cortical Adenoma<br>Vania Nosé, MD, PhD and Peter M. Sadow, MD, PhD<br>480 Aldosterone-Producing Adenoma<br>Vania Nosé, MD, PhD and Patricia Nogueira de Sa, MD<br>486 Cortisol-Secreting Adrenal Cortical Adenoma<br>Vania Nosé, MD, PhD and Peter M. Sadow, MD, PhD<br>492 Sex Hormone-Producing Adrenal Cortical Adenoma<br>Vania Nosé, MD, PhD and Peter M. Sadow, MD, PhD<br>494 Oncocytic Adrenal Cortical Adenoma<br>Vania Nosé, MD, PhD and Peter M. Sadow, MD, PhD<br>498 Adrenal Cortical Carcinoma<br>Vania Nosé, MD, PhD and Ying-Hsia Chu, MD<br>510 Adrenal Cortical Neoplasms in Children<br>Vania Nosé, MD, PhD<br><br>ADRENAL MEDULLA AND PARAGANGLIA<br>518 Adrenal Medullary Hyperplasia<br>Vania Nosé, MD, PhD<br>522 Pheochromocytoma and Paraganglioma<br>Vania Nosé, MD, PhD, Arthur S. Tischler, MD, and Ying-Hsia Chu, MD<br>534 Composite Pheochromocytoma and Composite Paraganglioma<br>Vania Nosé, MD, PhD and Arthur S. Tischler, MD<br>540 Neuroblastic Tumors of Adrenal Gland<br>Vania Nosé, MD, PhD<br><br>ADRENAL MESENCHYMAL AND STROMAL TUMORS<br>552 Primary Adrenal Myelolipoma<br>Vania Nosé, MD, PhD<br>556 Primary Adrenal Melanoma<br>Vania Nosé, MD, PhD<br>560 Primary Adrenal Benign Connective Tissue Tumor<br>Vania Nosé, MD, PhD<br>562 Primary Adrenal Angiosarcoma<br>Vania Nosé, MD, PhD<br>566 Primary Adrenal Leiomyosarcoma<br>Vania Nosé, MD, PhD<br>570 Metastasis to Adrenal Gland<br>Vania Nosé, MD, PhD<br><br>PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF ADRENAL GLAND<br>574 Adrenal Cortical Carcinoma Protocol<br>Vania Nosé, MD, PhD<br><br>SECTION 4: PITUITARY GLAND<br>NONNEOPLASTIC<br>578 Hypophysitis, Pituitary Gland<br>M.Beatriz S. Lopes, MD, PhD<br>582 Hyperplasia, Pituitary Gland<br>M.Beatriz S. Lopes, MD, PhD<br>584 Sarcoidosis, Pituitary Gland<br>M.Beatriz S. Lopes, MD, PhD and Vania Nosé, MD, PhD<br>588 Infarction, Pituitary Gland<br>M.Beatriz S. Lopes, MD, PhD<br>590 Sheehan Syndrome, Pituitary Gland<br>M.Beatriz S. Lopes, MD, PhD<br>592 Cystic Lesions of Sellar Region<br>M.Beatriz S. Lopes, MD, PhD<br>596 Empty Sella Syndrome<br>M.Beatriz S. Lopes, MD, PhD</p><p>NEOPLASTIC ANTERIOR NEUROENDOCRINE NEOPLASMS<br>598 Pituitary Neuroendocrine Tumor/Adenoma<br>M.Beatriz S. Lopes, MD, PhD and Vania Nosé, MD, PhD<br>604 Somatotroph PitNET/Adenoma<br>M.Beatriz S. Lopes, MD, PhD<br>608 Lactotroph PitNET/Adenoma<br>M.Beatriz S. Lopes, MD, PhD<br>612 Thyrotroph PitNET/Adenoma<br>M.Beatriz S. Lopes, MD, PhD<br>616 Plurihormonal PitNET/Adenoma<br>M.Beatriz S. Lopes, MD, PhD<br>620 Corticotroph PitNET/Adenoma<br>M.Beatriz S. Lopes, MD, PhD<br>624 Gonadotroph PitNET/Adenoma<br>M.Beatriz S. Lopes, MD, PhD<br>628 Null Cell PitNET/Adenoma<br>M.Beatriz S. Lopes, MD, PhD<br>630 Metastatic Pituitary Neuroendocrine Tumor<br>Vania Nosé, MD, PhD and M. Beatriz S. Lopes, MD, PhD<br><br>OTHER ANTERIOR PITUITARY TUMORS<br>634 Adamantinomatous Craniopharyngioma<br>M.Beatriz S. Lopes, MD, PhD<br>636 Papillary Craniopharyngioma<br>M.Beatriz S. Lopes, MD, PhD<br>638 Pituitary Blastoma<br><br>POSTERIOR PITUITARY NEOPLASMS<br>642 Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor of Sella<br>M.Beatriz S. Lopes, MD, PhD<br><br>NEURONAL TUMORS<br>646 Gangliocytoma<br>M.Beatriz S. Lopes, MD, PhD<br>650 Neuronal Cell Tumors, Pituitary<br>M.Beatriz S. Lopes, MD, PhD<br><br>OTHER PITUITARY TUMORS<br>652 Metastasis to Pituitary Gland<br>M.Beatriz S. Lopes, MD, PhD<br>654 Mesenchymal and Hematopoietic Tumors, Pituitary Gland<br>M.Beatriz S. Lopes, MD, PhD<br><br>PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH PRIMARY PITUITARY TUMORS<br>658 Protocol for Examination of Specimens From Patients With Primary Pituitary Tumors<br>Vania Nosé, MD, PhD and M. Beatriz S. Lopes, MD, PhD<br><br>SECTION 5: ENDOCRINE PANCREAS<br>664 Pancreatic Neuroendocrine Neoplasms<br>Vania Nosé, MD, PhD<br><br>PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF ENDOCRINE PANCREAS<br>674 Pancreatic Neuroendocrine Carcinoma Protocol<br>Vania Nosé, MD, PhD<br><br>SECTION 6: ENDOCRINE SKIN<br>678 Merkel Cell Carcinoma<br>Lori A. Erickson, MD<br><br>SECTION 7: FAMILIAL TUMORSYNDROMES MAJOR ENDOCRINE GLAND AFFECTED THYROID GLAND<br>690 DICER1 Syndrome<br>Vania Nosé, MD, PhD and Michelle Menon Miyake, MD<br>700 Familial Thyroid Carcinoma<br>Vania Nosé, MD, PhD<br>706 McCune-Albright Syndrome<br>Vania Nosé, MD, PhD<br>712 Multiple Endocrine Neoplasia Type 2 (MEN2)<br>Vania Nosé, MD, PhD<br>720 Nonsyndromic Familial Follicular Cell-Derived Thyroid Carcinoma<br>Vania Nosé, MD, PhD<br>726 PTEN Hamartoma Tumor Syndromes<br>Vania Nosé, MD, PhD<br>734 Syndromic Familial Follicular Cell-Derived Thyroid Carcinoma<br>Vania Nosé, MD, PhD<br><br>PARATHYROID GLAND<br>742 Familial Isolated Hyperparathyroidism<br>Vania Nosé, MD, PhD and Lori A. Erickson, MD<br>746 Hyperparathyroidism-Jaw Tumor Syndrome<br>Vania Nosé, MD, PhD and Lori A. Erickson, MD<br>754 Multiple Endocrine Neoplasia Type 1 (MEN1)<br>Vania Nosé, MD, PhD and Michelle Menon Miyake, MD<br>762 Multiple Endocrine Neoplasia Type 4 (MEN4)<br>Vania Nosé, MD, PhD and Michelle Menon Miyake, MD<br><br>ADRENAL GLAND AND PARAGANGLIA<br>768 Beckwith-Wiedemann Syndrome<br>Patricia Nogueira de Sa, MD and Vania Nosé, MD, PhD<br>776 Carney Complex<br>Vania Nosé, MD, PhD<br>784 Hereditary Neuroblastoma<br>Vania Nosé, MD, PhD<br>788 Hereditary Paraganglioma/Pheochromocytoma Syndromes<br>Vania Nosé, MD, PhD<br>796 Multiple Endocrine Neoplasia Type 5,MAX-Related<br>Vania Nosé, MD, PhD<br>798 Neurofibromatosis Type 1<br>Michelle Menon Miyake, MD and Vania Nosé, MD, PhD<br>806 von Hippel-Lindau Syndrome<br>Vania Nosé, MD, PhD<br>814 SDH-Deficient Pheochromocytoma and Paraganglioma<br>Vania Nosé, MD, PhD and Arthur S. Tischler, MD<br><br>PANCREAS<br>820 Glucagon Cell Hyperplasia and Neoplasia<br>Vania Nosé, MD, PhD<br>824 Hereditary and Familial Pancreatic Cancer Syndrome<br>Daniel C. Chung, MD and Vania Nosé, MD, PhD<br>828 MAFA-Related Familial Insulinomatosis<br>Vania Nosé, MD, PhD<br>830 Pancreatic Neuroendocrine Tumor Syndromes<br>842 Ectopic (Paraneoplastic) Syndromes<br>Lori A. Erickson, MD</p>