<p>SECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEEN</p> <p>NORMAL HISTOLOGY</p> <p>4 Introduction to Spleen</p> <p>Mohammad A. Vasef, MD and Jeremy C. Wallentine, MD</p> <p>12 Imaging of Splenic Disorders</p> <p>Mohammad A. Vasef, MD</p> <p>18 Handling, Processing, and Gross Pathology of Spleen</p> <p>Mohammad A. Vasef, MD</p> <p>26 Fine-Needle Aspiration and Core Biopsy of Spleen</p> <p>Mohammad A. Vasef, MD</p> <p>32 Immunohistochemistry of Spleen</p> <p>Aaron Auerbach, MD, MPH</p> <p>40 Flow Cytometry</p> <p>Nadine Aguilera, MD</p> <p>46 Molecular Techniques</p> <p>Nadine Aguilera, MD</p> <p>SECTION 2: NONNEOPLASTIC SPLENIC DISORDERS</p> <p>LYMPHOID HYPERPLASIA</p> <p>54 Florid Follicular Hyperplasia</p> <p>Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH</p> <p>56 Autoimmune Disease</p> <p>Nadine Aguilera, MD</p> <p>62 HIV in Spleen</p> <p>Nadine Aguilera, MD</p> <p>68 Castleman Disease</p> <p>Nadine Aguilera, MD</p> <p>70 Marginal Zone Hyperplasia</p> <p>Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH</p> <p>GRANULOMATOUS LESIONS/DISORDERS</p> <p>72 Lipogranulomas</p> <p>Jeffrey Vos, MD</p> <p>78 Sarcoidosis</p> <p>Ellina Hall, DO and Aaron Auerbach, MD, MPH</p> <p>82 Chronic Granulomatous Disease</p> <p>Aaron Auerbach, MD, MPH</p> <p>INFECTIONS</p> <p>86 Mycobacteriosis</p> <p>Nadine Aguilera, MD </p> <p>90 Selected Bacterial Infections </p> <p>Aaron Auerbach, MD, MPH </p> <p>94 Candidiasis </p> <p>Aaron Auerbach, MD, MPH</p> <p>96 Histoplasmosis</p> <p>Nadine Aguilera, MD</p> <p>98 Cryptococcosis</p> <p>Nadine Aguilera, MD</p> <p>100 Coccidioidomycosis</p> <p>Aaron Auerbach, MD, MPH</p> <p>104 Pneumocystosis</p> <p>Aaron Auerbach, MD, MPH</p> <p>108 Infectious Mononucleosis</p> <p>Nadine Aguilera, MD</p> <p>112 Cytomegalovirus Infection</p> <p>Nadine Aguilera, MD</p> <p>114 Herpes Simplex Virus Infection</p> <p>Aaron Auerbach, MD, MPH and Nadine Aguilera, MD</p> <p>116 Echinococcosis</p> <p>Aaron Auerbach, MD, MPH</p> <p>120 Malaria</p> <p>Nadine Aguilera, MD</p> <p>NONINFECTIOUS CYSTS</p> <p>122 Epithelial Cyst</p> <p>Ellina Hall, DO and Aaron Auerbach, MD, MPH</p> <p>124 False Cyst</p> <p>Ellina Hall, DO and Aaron Auerbach, MD, MPH</p> <p>NONNEOPLASTIC VASCULAR PROCESSES</p> <p>126 Chronic Passive Congestion</p> <p>Ellina Hall, DO and Aaron Auerbach, MD, MPH</p> <p>128 Infarct</p> <p>Jeffrey Vos, MD</p> <p>136 Peliosis</p> <p>Ellina Hall, DO and Aaron Auerbach, MD, MPH</p> <p>138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>RED CELL DISORDERS</p> <p>144 Sickle Cell Disease</p> <p>Aaron Auerbach, MD, MPH and Ellina Hall, DO</p> <p>146 Thalassemia</p> <p>Nadine Aguilera, MD and Aaron Auerbach, MD, MPH</p> <p>150 Hereditary Spherocytosis</p> <p>Nadine Aguilera, MD</p> <p>152 Thrombotic Thrombocytopenic Purpura</p> <p>Aaron Auerbach, MD, MPH</p> <p>MISCELLANEOUS LESIONS/DISORDERS</p> <p>158 Heterotaxy Syndromes</p> <p>Aaron Auerbach, MD, MPH</p> <p>160 Congenital Splenic Abnormalities</p> <p>Nadine Aguilera, MD</p> <p>164 Extramedullary Hematopoiesis</p> <p>Ellina Hall, DO and Aaron Auerbach, MD, MPH</p> <p>166 Gamna-Gandy Bodies</p> <p>Nadine Aguilera, MD</p> <p>168 Hemophagocytic Lymphohistiocytosis</p> <p>Nadine Aguilera, MD</p> <p>174 Immune Thrombocytopenic Purpura</p> <p>Ellina Hall, DO and Aaron Auerbach, MD, MPH</p> <p>178 Niemann-Pick Disease</p> <p>Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD</p> <p>184 Gaucher Disease</p> <p>Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD</p> <p>188 Sea-Blue (Ceroid) Histiocytosis</p> <p>Mohammad A. Vasef, MD</p> <p>192 Gangliosidosis Lysosomal Disorder</p> <p>Mohammad A. Vasef, MD</p> <p>194 Therapy Effect on Spleen</p> <p>Aaron Auerbach, MD, MPH</p> <p>202 Traumatic and Nontraumatic Splenic Injuries</p> <p>Mohammad A. Vasef, MD</p> <p>SECTION 3: NEOPLASTIC SPLENIC DISORDERS</p> <p>BENIGN MESENCHYMAL LESIONS</p> <p>208 Introduction to Vascular Lesions</p> <p>Nadine Aguilera, MD</p> <p>210 Hemangioma</p> <p>Nadine Aguilera, MD</p> <p>218 Lymphangioma</p> <p>Nadine Aguilera, MD</p> <p>222 Littoral Cell Angioma</p> <p>Nadine Aguilera, MD</p> <p>228 Inflammatory Pseudotumor</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>236 Postchemotherapy Histiocyte-Rich Pseudotumor of Spleen</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>242 Splenic Hamartoma</p> <p>Nadine Aguilera, MD</p> <p>246 Myelolipoma</p> <p>Aaron Auerbach, MD, MPH</p> <p>MALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS </p> <p>248 Angiosarcoma</p> <p>Nadine Aguilera, MD</p> <p>256 Hemangioendothelioma</p> <p>Nadine Aguilera, MD</p> <p>258 Kaposi Sarcoma</p> <p>Nadine Aguilera, MD</p> <p>260 Leiomyosarcoma</p> <p>Aaron Auerbach, MD, MPH</p> <p>266 Gastrointestinal Stromal Tumor</p> <p>Aaron Auerbach, MD, MPH</p> <p>272 Follicular Dendritic Cell Sarcoma</p> <p>Aaron Auerbach, MD, MPH</p> <p>280 Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>286 Langerhans Cell Histiocytosis</p> <p>Guanghua Wang, MD</p> <p>292 Histiocytic Sarcoma</p> <p>Nadine Aguilera, MD</p> <p>LYMPHOMA</p> <p>300 Introduction to Lymphoma</p> <p>Mohammad A. Vasef, MD</p> <p>310 Splenic Marginal Zone Lymphoma</p> <p>Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD</p> <p>318 Hairy Cell Leukemia</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>326 Hairy Cell Leukemia Variant</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>334 Lymphoplasmacytic Lymphoma</p> <p>Aaron Auerbach, MD, MPH</p> <p>342 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>350 Follicular Lymphoma</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>358 Mantle Cell Lymphoma</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>366 Leukemic Nonnodal Mantle Cell Lymphoma</p> <p>Mohammad A. Vasef, MD</p> <p>370 Splenic Diffuse Red Pulp B-Cell Lymphoma</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>376 B-Cell Prolymphocytic Leukemia</p> <p>Aaron Auerbach, MD, MPH and Nadine Aguilera, MD</p> <p>378 Diffuse Large B-Cell Lymphoma</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>384 Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst</p> <p>Mohammad A. Vasef, MD</p> <p>390 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma</p> <p>Jeffrey Vos, MD</p> <p>398 Burkitt Lymphoma</p> <p>Aaron Auerbach, MD, MPH</p> <p>406 Classic Hodgkin Lymphoma</p> <p>Jeffrey Vos, MD</p> <p>416 Nodular Lymphocyte-Predominant Hodgkin Lymphoma</p> <p>Aaron Auerbach, MD, MPH</p> <p>426 Peripheral T-Cell Lymphoma, Unspecified</p> <p>Mohammad A. Vasef, MD</p> <p>432 Hepatosplenic T-Cell Lymphoma</p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>440 T-Cell Prolymphocytic Leukemia</p> <p>Mohammad A. Vasef, MD</p> <p>448 T-Cell Large Granular Lymphocytic Leukemia </p> <p>Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD</p> <p>456 Aggressive NK-Cell Leukemia</p> <p>Aaron Auerbach, MD, MPH</p> <p>462 Transformation of Splenic Disorders</p> <p>Nadine Aguilera, MD</p> <p>LEUKEMIA</p> <p>466 Acute Myeloid Leukemia</p> <p>Nadine Aguilera, MD</p> <p>474 Lymphoblastic Leukemia/Lymphoma</p> <p>Nadine Aguilera, MD</p> <p>CHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES</p> <p>480 Myeloproliferative Neoplasm Overview</p> <p>Nadine Aguilera, MD</p> <p>482 Chronic Myeloid Leukemia, BCR::ABL1 Positive</p> <p>Nadine Aguilera, MD</p> <p>488 Essential Thrombocythemia</p> <p>Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH</p> <p>492 Polycythemia Vera</p> <p>Guanghua Wang, MD</p> <p>496 Primary Myelofibrosis</p> <p>Jeffrey Vos, MD</p> <p>506 Mastocytosis</p> <p>Mohammad A. Vasef, MD</p> <p>514 Chronic Myelomonocytic Leukemia</p> <p>Mohammad A. Vasef, MD</p> <p>PLASMA CELL-ASSOCIATED DISORDERS</p> <p>520 Amyloidosis</p> <p>Nadine Aguilera, MD</p> <p>526 Heavy Chain Disease</p> <p>Aaron Auerbach, MD, MPH</p> <p>530 Plasma Cell Myeloma/Plasmacytoma</p> <p>Nadine Aguilera, MD and Aaron Auerbach, MD, MPH</p> <p>METASTASIS</p> <p>534 Metastatic Tumors</p> <p>Ellina Hall, DO and Aaron Auerbach, MD, MPH</p>