<p>SECTION 1: LIVER</p> <p>INHERITED, METABOLIC, AND DEVELOPMENTAL DISORDERS</p> <p>4 Glycogen Storage Disease, Hepatic<br>Joseph Misdraji, MD, Lisa Yerian, MD, and Grace E. Kim, MD<br>10 Tyrosinemia<br>Joseph Misdraji, MD<br>12 Niemann-Pick Disease<br>Joseph Misdraji, MD<br>14 Gaucher Disease<br>Joseph Misdraji, MD<br>16 Neonatal Hemochromatosis<br>Joseph Misdraji, MD<br>18 Porphyrin Metabolism Disorders<br>Maria Westerhoff, MD and Joseph Misdraji, MD<br>24 Dubin-Johnson Syndrome<br>Joseph Misdraji, MD and Sanjay Kakar, MD<br>26 Gilbert Disease<br>Joseph Misdraji, MD and Sanjay Kakar, MD<br>28 Progressive Familial Intrahepatic Cholestasis<br>Joseph Misdraji, MD<br>36 Cystic Fibrosis, Hepatic<br>Joseph Misdraji, MD<br>40 Hereditary Hemochromatosis<br>Joseph Misdraji, MD and Laura W. Lamps, MD<br>44 Wilson Disease<br>Joseph Misdraji, MD and Laura W. Lamps, MD<br>50 Alpha-1-Antitrypsin Deficiency<br>Nicole C. Panarelli, MD, Kari D. Caradine, MD, and Laura<br>W. Lamps, MD<br>54 Congenital Hepatic Fibrosis<br>Romil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD<br>56 Polycystic Liver Disease<br>Romil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD<br>58 Caroli Disease<br>Romil Saxena, MBBS, MD, FRCPath (UK)<br> INFECTIOUS DISORDERS <br>60 Overview of Hepatitis<br>Nicole C. Panarelli, MD and Laura W. Lamps, MD<br>66 Acute Viral Hepatitis<br>Nicole C. Panarelli, MD and Lisa Yerian, MD<br>70 Hepatitis B<br>Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD<br>74 Hepatitis C<br>Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD<br>78 Hepatitis E<br>Maria Westerhoff, MD<br>82 Epstein-Barr Virus<br>Laura W. Lamps, MD, Maria Westerhoff, MD, and Hanlin<br>L. Wang, MD, PhD<br>86 Cytomegalovirus<br>Laura W. Lamps, MD<br>88 Herpes Simplex Virus<br>Sanjay Kakar, MD<br>90 Adenovirus<br>Maria Westerhoff, MD and Hanlin L. Wang, MD, PhD<br>92 Pyogenic Abscess<br>Laura W. Lamps, MD<br>96 Sepsis in Liver<br>Laura W. Lamps, MD<br>98 Mycobacterium tuberculosis<br>Laura W. Lamps, MD<br>102 Atypical Mycobacteria<br>Laura W. Lamps, MD<br>106 Cat-Scratch Disease<br>Laura W. Lamps, MD<br>108 Candidiasis<br>Laura W. Lamps, MD<br>110 Histoplasmosis<br>Joseph Misdraji, MD and Laura W. Lamps, MD<br>114 Cryptococcosis<br>Laura W. Lamps, MD<br>116 Amebiasis<br>Laura W. Lamps, MD<br>120 Schistosomiasis<br>Laura W. Lamps, MD<br>122 Echinococcosis<br>Laura W. Lamps, MD</p> <p>CHRONIC CHOLESTATIC AND AUTOIMMUNE DISORDERS<br>124 Autoimmune Hepatitis<br>Nicole C. Panarelli, MD and Lisa Yerian, MD<br>130 Primary Biliary Cholangitis<br>Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD<br>136 Primary Sclerosing Cholangitis<br>Hanlin L. Wang, MD, PhD<br>142 Ischemic Cholangitis<br>Maria Westerhoff, MD and Lisa Yerian, MD<br>144 Large Bile Duct Obstruction<br>Maria Westerhoff, MD and Laura W. Lamps, MD<br>148 Idiopathic Adulthood Ductopenia<br>Hanlin L. Wang, MD, PhD<br>PEDIATRIC CHOLESTATIC DISORDERS <br>150 Biliary Atresia<br>Romil Saxena, MBBS, MD, FRCPath (UK), Grace E. Kim, MD, and Matthew M. Yeh, MD, PhD<br>154 Idiopathic Neonatal Hepatitis<br>Romil Saxena, MBBS, MD, FRCPath (UK), Grace E. Kim, MD, and Matthew M. Yeh, MD, PhD<br>156 Syndromic Paucity of Intrahepatic Bile Ducts<br>(Alagille Syndrome)<br>Joseph Misdraji, MD, Romil Saxena, MBBS, MD, FRCPath (UK), and Matthew M. Yeh, MD, PhD<br>160 Nonsyndromic Paucity of Intrahepatic Bile Ducts<br>Romil Saxena, MBBS, MD, FRCPath (UK), Joseph Misdraji, MD, and Matthew M. Yeh, MD, PhD<br> DRUG/TOXIN-RELATED HEPATITIS <br>164 Drug-Related Acute Hepatitis<br>Sanjay Kakar, MD<br>170 Drug-Induced Acute Hepatic Failure<br>Sanjay Kakar, MD<br>174 Drug-Induced Cholestatic Liver Injury<br>Sanjay Kakar, MD<br>176 Drug-Related Granulomatous Hepatitis<br>Laura W. Lamps, MD<br>180 Drug-Related Steatohepatitis/Phospholipidosis<br>Laura W. Lamps, MD<br>184 Reye Syndrome<br>Romil Saxena, MBBS, MD, FRCPath (UK) and Lisa Yerian, MD<br>186 Drug-Related Cholangitis/Ductopenia<br>Maria Westerhoff, MD<br>192 Hepatic Stellate Cell Hyperplasia<br>Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD<br> FATTY LIVER DISEASES <br>194 Alcoholic Liver Disease<br>Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD<br>200 Nonalcoholic Steatohepatitis<br>Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD<br>208 Glycogenic Hepatopathy<br>Maria Westerhoff, MD and Lisa Yerian, MD<br>210 Fatty Liver of Pregnancy<br>Nicole C. Panarelli, MD and Lisa Yerian, MD</p> <p>VASCULAR DISORDERS </p> <p>212 Portal Venous Obstruction<br>Hanlin L. Wang, MD, PhD<br>214 Hepatoportal Sclerosis<br>Hanlin L. Wang, MD, PhD<br>216 Hepatic Venous Outflow Obstruction<br>Sanjay Kakar, MD<br>220 Venoocclusive Disease<br>Sanjay Kakar, MD<br>222 Amyloidosis<br>Sanjay Kakar, MD<br>224 Ischemia<br> Rondell Graham, MBBS and Lisa Yerian, MD<br>226 Nodular Regenerative Hyperplasia<br>Sanjay Kakar, MD<br> TRANSPLANTATION PATHOLOGY <br>228 Ischemia Reperfusion Injury<br>Romil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD<br>230 Antibody-Mediated Rejection<br>Hanlin L. Wang, MD, PhD and Romil Saxena, MBBS, MD, FRCPath (UK)<br>232 T-Cell-Mediated Rejection (Acute Cellular Rejection)<br>Romil Saxena, MBBS, MD, FRCPath (UK)<br>236 Chronic Rejection<br>Romil Saxena, MBBS, MD, FRCPath (UK) and Matthew M. Yeh, MD, PhD<br>238 Central Perivenulitis/Parenchymal Rejection<br>Rondell Graham, MBBS<br>240 Hepatic Artery Thrombosis<br>Rondell Graham, MBBS and Lisa Yerian, MD<br>242 Graft-vs.-Host Disease<br>Rondell Graham, MBBS and Lisa Yerian, MD<br> TUMORS OF THE LIVER <br>244 Hepatic Adenoma<br>Sanjay Kakar, MD and Matthew M. Yeh, MD, PhD<br>252 Focal Nodular Hyperplasia<br>Sanjay Kakar, MD<br>256 Regenerative and Dysplastic Nodules<br>Sanjay Kakar, MD<br>262 Hepatocellular Carcinoma and Variants<br>Sanjay Kakar, MD<br>274 Fibrolamellar Carcinoma<br>Rondell Graham, MBBS<br>278 Combined Hepatocellular-Cholangiocarcinoma<br>Maria Westerhoff, MD<br>282 Hepatoblastoma<br>Rondell Graham, MBBS<br>286 Bile Duct Adenoma<br>Rondell Graham, MBBS and Sanjay Kakar, MD<br>288 von Meyenburg Complex (Biliary Microhamartoma) Sanjay Kakar, MD, Laura W. Lamps, MD, and Rondell Graham, MBBS<br>290 Mucinous Cystic Neoplasm, Liver<br>Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD<br>294 Intrahepatic Cholangiocarcinoma<br>Rondell Graham, MBBS and Sanjay Kakar, MD<br>298 Intrahepatic Cholangiocarcinoma Histologic Subtypes<br>Rondell Graham, MBBS<br>302 Intraductal Papillary Neoplasm<br>Rondell Graham, MBBS<br>304 Hemangioma<br>Rondell Graham, MBBS<br>306 Angiomyolipoma<br>Rondell Graham, MBBS and Lisa Yerian, MD<br>310 Hepatic Small Vessel Neoplasm/Anastamosing Hemangioma<br>Maria Westerhoff, MD<br>314 Epithelioid Hemangioendothelioma<br>Sanjay Kakar, MD<br>316 Infantile Hemangioma<br>Sanjay Kakar, MD<br>318 Angiosarcoma<br>Sanjay Kakar, MD<br>320 Mesenchymal Hamartoma<br>Nicole C. Panarelli, MD, Hanlin L. Wang, MD, PhD, and Sanjay Kakar, MD<br>322 Embryonal Sarcoma<br>Nicole C. Panarelli, MD<br>324 Inflammatory Pseudotumor<br>Joseph Misdraji, MD<br>330 Segmental Atrophy (Nodular Elastosis)<br>Joseph Misdraji, MD<br>332 Hepatectomy Specimen Handling<br>Rondell Graham, MBBS and Laura W. Lamps, MD<br> MISCELLANEOUS HEPATIC DISORDERS <br>334 Langerhans Cell Histiocytosis<br>Maria Westerhoff, MD and Hanlin L. Wang, MD, PhD<br>338 Hemophagocytic Syndromes<br>Hanlin L. Wang, MD, PhD</p> <p> DEVELOPMENTAL/CONGENITAL <br>342 Congenital Pancreatic Cyst<br>Hanlin L. Wang, MD, PhD<br>344 Cystic Fibrosis, Pancreas<br>Hanlin L. Wang, MD, PhD<br>346 Nesidioblastosis<br>Hanlin L. Wang, MD, PhD<br>348 Choledochal Cyst<br>Romil Saxena, MBBS, MD, FRCPath (UK) and Laura W. Lamps, MD<br>350 Cholelithiasis<br>Laura W. Lamps, MD<br>352 Acute Cholecystitis<br>Sanjay Kakar, MD<br>354 Chronic Cholecystitis<br>Sanjay Kakar, MD<br>356 Xanthogranulomatous Cholecystitis<br>Laura W. Lamps, MD<br>358 Eosinophilic Cholecystitis<br>Laura W. Lamps, MD<br>360 Polyarteritis Nodosa and Other Vasculitides<br>Nicole C. Panarelli, MD<br>362 Parasitic Infection<br>Laura W. Lamps, MD</p> <p>NONNEOPLASTIC AND INFLAMMATORY DISORDERS OF THE PANCREAS</p> <p>366 Acute Pancreatitis<br>Grace E. Kim, MD and Alyssa M. Krasinskas, MD<br>368 Chronic Pancreatitis<br>Alyssa M. Krasinskas, MD and Lisa Yerian, MD<br>372 Autoimmune Pancreatitis<br>Alyssa M. Krasinskas, MD and Lisa Yerian, MD<br>376 Groove Pancreatitis<br>Alyssa M. Krasinskas, MD, Lisa Yerian, MD, and Vikram Deshpande, MD<br>378 Infectious Pancreatitis<br>Laura W. Lamps, MD<br>380 Pseudocysts<br>Alyssa M. Krasinskas, MD, Vikram Deshpande, MD, and Lisa Yerian, MD<br>382 Diabetes Mellitus<br>Laura W. Lamps, MD<br>384 Lymphoepithelial Cyst of the Pancreas<br>Alyssa M. Krasinskas, MD and Lisa Yerian, MD</p> <p>TUMORS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREE<br>386 Noninvasive Epithelial Polypoid Lesions</p> <p>390 Nicole C. Panarelli, MD and Sanjay Kakar, MD<br>Carcinoma of Gallbladder</p> <p>396 Nicole C. Panarelli, MD and Laura W. Lamps, MD<br>Carcinoma of Extrahepatic Bile Ducts</p> <p>402 Rondell Graham, MBBS and Laura W. Lamps, MD<br>Squamous/Adenosquamous Carcinoma, Gallbladder</p> <p>404 Hanlin L. Wang, MD, PhD<br>Neuroendocrine Neoplasms of Gallbladder</p> <p>408 Hanlin L. Wang, MD, PhD<br>Granular Cell Tumor</p> <p>410 Nicole C. Panarelli, MD<br>Embryonal Rhabdomyosarcoma</p> <p>412 Hanlin L. Wang, MD, PhD<br>Adenomyoma</p> <p>414 Nicole C. Panarelli, MD and Lisa Yerian, MD<br>Nonneoplastic Polypoid Gallbladder Lesions<br> Nicole C. Panarelli, MD and Laura W. Lamps, MD<br> TUMORS OF THE PANCREAS <br>418 Pancreatic Intraepithelial Neoplasia<br>Alyssa M. Krasinskas, MD and Sanjay Kakar, MD<br>420 Ductal Adenocarcinoma, Including Variants Alyssa M. Krasinskas, MD, Sanjay Kakar, MD, and Mari Mino-Kenudson, MD<br>424 Undifferentiated Carcinoma<br>Wei Zheng, MD, Sanjay Kakar, MD, and Alyssa M. Krasinskas, MD<br>426 Adenosquamous Carcinoma, Pancreas<br>Alyssa M. Krasinskas, MD<br>428 Serous Cystadenoma<br>Sanjay Kakar, MD and Grace E. Kim, MD<br>432 Acinar Cell Cystadenoma<br>Maria Westerhoff, MD<br> </p> <p>436 Simple Mucinous Cyst<br>Maria Westerhoff, MD<br>438 Mucinous Cystic Neoplasm, Pancreas<br>Maria Westerhoff, MD<br>442 Intraductal Papillary Mucinous Neoplasm<br>Mari Mino-Kenudson, MD, Zaid Mahdi, MD, and Alyssa M. Krasinskas, MD<br>448 Intraductal Oncocytic Papillary Neoplasm<br>Alyssa M. Krasinskas, MD and Mari Mino-Kenudson, MD<br>450 Intraductal Tubulopapillary Neoplasm<br>Alyssa M. Krasinskas, MD and Mari Mino-Kenudson, MD<br>452 Acinar Cell Carcinoma<br>Laura W. Lamps, MD, Wei Zheng, MD, and Alyssa M. Krasinskas, MD<br>456 Pancreatoblastoma<br>Alyssa M. Krasinskas, MD, Laura W. Lamps, MD, and Matthew M. Yeh, MD, PhD<br>458 Dermoid Cyst<br>Zaid Mahdi, MD, Vikram Deshpande, MD, and Alyssa M. Krasinskas, MD<br>460 Poorly Differentiated Neuroendocrine Carcinoma,<br>Pancreas<br>Sanjay Kakar, MD<br>464 Well-Differentiated Neuroendocrine Tumor, Pancreas<br>Sanjay Kakar, MD<br>470 Solid-Pseudopapillary Tumors<br>Sanjay Kakar, MD<br> TUMORS OF THE AMPULLA <br>474 Ampullary Adenoma<br>Hanlin L. Wang, MD, PhD<br>476 Ampullary Adenocarcinoma and Variants<br>Hanlin L. Wang, MD, PhD<br>480 Well-Differentiated Neuroendocrine Tumor, Ampulla<br>Hanlin L. Wang, MD, PhD<br>482 Gangliocytic Paraganglioma<br>Maria Westerhoff, MD<br> SPECIMEN HANDLING, WHIPPLE <br>484 Specimen Handling, Whipple<br>Alyssa M. Krasinskas, MD and Laura W. Lamps, MD</p> <p> <br></p>