Bone Cancer

Bone Sarcomas and Bone Metastases - From Bench to Bedside

Specificaties
Gebonden, blz. | Engels
Elsevier Science | e druk, 2021
ISBN13: 9780128216668
Rubricering
Elsevier Science e druk, 2021 9780128216668
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. 

The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials.

Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease.

Specificaties

ISBN13:9780128216668
Taal:Engels
Bindwijze:Gebonden

Inhoudsopgave

<p>Epidemiology of Bone Cancer</p> <p>1. Osteoarchaeology: lessons to learn from the past</p> <p>2. Epidemiology of primary bone tumors and economical aspects of bone metastases</p> <p>Models of Bone Cancers and Technical Aspects</p> <p>Animal Models</p> <p>3. Animal models of bone sarcomas</p> <p>4. In vivo models used in studies of bone metastaes</p> <p>5. Zebrafish models for studying bone tumors</p> <p>Mathematic models and machine learning</p> <p>6. Use of machine learning in bone cancers</p> <p>7. Artifical intelligence for bone cancer imaging</p> <p>Preparation of tissue samples: technical aspects</p> <p>8. Technical aspects: how do we best prepare bone samples for proper histological analysis?</p> <p>Bone Microenvironment and Bone Cancer</p> <p>Bone niche</p> <p>9. Bone niche and bone metastases </p> <p>10. Bone: a fertil soil for tumor development</p> <p>11. Osteomimicry: old concepts and new findings </p> <p>Dialog between cancer cells and bone cells</p> <p>12. Role of mesenchymal stem cells in bone cancers, initiation, propagation and metastasis </p> <p>13. Technical approaches for studying the communications between osteocytes and cancer cells</p> <p>14. Osteocytes and bone cancers</p> <p>15. Immune functions of osteoclasts: new insights for bone cancers</p> <p>16. Immune infiltrate in bone sarcomas</p> <p>17. Macrophages and pathophysiology of bone cancers</p> <p>Mediators of cell communications</p> <p>18. Growth factors, cytokines and pediatric malignant primary bones tumors</p> <p>19. The role of NFkB in bone cancer</p> <p>20. TGF-beta and bone cancers: a specific focus </p> <p>21. Extracellular vesicles, tumor growth and metastatic process</p> <p>22. Connexin43 and development of primary bone tumors : osteosarcoma and Ewing’s sarcoma</p> <p>23. The role of endocannabinoid system in bone cancer</p> <p>Metabolism</p> <p>24. Impact of the microenvironment acidosis on bone cancers </p> <p>25. Hypoxic niche and bone cancers</p> <p>26. Metabolism and bone cancers</p> <p>Bone Tumor Heterogeneity, Plasticity and Biomarkers</p> <p>Heterogeneity and plasticity</p> <p>27. EMT process in bone metastasis</p> <p>28. Cancer stem cells and clonal evolution in bone sarcomas</p> <p>29. Dormancy in cancer bone metastasis</p> <p>Biomarkers</p> <p>30. Bone Remodelling Markers and Bone Cancer </p> <p>31. Epigenetic Heterogeneity in Primary Bone Cancers </p> <p>32. miRNA implication in therapeutic resistance and metastatic dissemination of bone-associated tumors</p> <p>33. MicroRNAs and bone metastasis: how small RNAs regulate secondary tumour formation and progression in the skeleton</p> <p>34. Long-non coding RNA and bone sarcoma</p> <p>35. Liquid biopsy and circulating tumor cells in bone sarcomas: identification of new biomarkers and analysis of the tumor heterogeneity</p> <p>36. Disseminated tumor cells in bone marrow of cancer patients </p> <p>II. PRIMARY BONE TUMORS</p> <p>Biological aspects</p> <p>37. Cytogenetics of bone sarcomas </p> <p>38. Genetic aspects of primary bone tumors</p> <p>39. Markers of bone sarcomas</p> <p>40. Molecular pathology of osteosarcoma</p> <p>41. Genomic and proteomic profiling of osteosarcoma </p> <p>42. Ewing sarcoma family of tumors</p> <p>43. Molecular aspects of Ewing sarcomas </p> <p>44. Osteoclast-rich lesions: a clinical and molecular overview</p> <p>45. Biology of cartilage tumor family</p> <p>Clinical aspects and Perspectives</p> <p>Imaging</p> <p>46. Imaging of bone sarcomas </p> <p>Therapeutic approaches</p> <p>47. Current therapeutic approaches of bone sarcomas</p> <p>48. Surgical approaches of bone sarcomas: Margins and clinical impact </p> <p>49. Apoptosis and drug resistance in malignant bone tumors: impact on the clinical practices </p> <p>50. Chondrosarcoma of Bone: Diagnosis and Therapy </p> <p>51. Radiotherapy and Primary bone tumors</p> <p>52. New therapeutic advances of bone sarcomas</p> <p>III. BONE METASTASES</p> <p>Biological aspects</p> <p>53. The histopathology of skeletal Metastases </p> <p>54. Indentification of new therapeutic targets of bone cancers by proteomic strategies </p> <p>Clinical aspects and Perspectives</p> <p>Imaging</p> <p>55. Interventional radiologic techniques in management of bone tumors </p> <p>56. Diagnosis of bone metastases in urological malignancies – an update</p> <p>Bone pain</p> <p>57. Mechanisms and management of bone cancer pain </p> <p>58. Involvement of sympathic nerves in bone mestastasis</p> <p>59. Pain control with palliative radiotherapy in patients with bone metastases </p> <p>60. Palliative care of bone metastases</p> <p>Therapeutic approaches</p> <p>61. Radiotherapy of bone metastases</p> <p>62. Cellular and molecular actions of bisphosphonates: therapeutic interest in tumor-associated bone diseases</p> <p>63. Bone-Targeted agents and skeletal-related events in breast cancer patients with bone metastases</p> <p>64. Bone metastases – current status of bone-targeted treatments</p> <p>65. Therapies of bone metastases in castration-resistant prostate cancer</p> <p>66. Therapy with bone-targeting radiopharmaceuticals</p> <p>67. Therapeutic approaches of bone metastases associated with breast cancer</p> <p>MYELOMA: A BONE ASSOCIATED DISEASE</p> <p>68. Biological relationship between bone and myeloma cells</p> <p>69. Recent therapeutic approaches in myeloma</p>

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        Bone Cancer