Recent Highlights in the Discovery and Optimization of Crop Protection Products

<p>Preface<br>Peter Maienfisch and Sven Mangelinckx<br>1. Recent innovation in crop protection research<br>Peter Maienfisch and Sven Mangelinckx<br>2. Status and potential of bioprotection products for crop protection<br>Pamela G. Marrone<br>3. Research and development of green pesticides in China<br>Xusheng Shao, Zhong Li and Xuhong Qian<br>4. Agrochemical disease control: The story so far<br>Clemens Lamberth, Stefano Rendine and Sarah Sulzer-Mosse<br>5. Plant defense priming in the field: a review<br>Willem Desmedt, Bartel Vanholme and Tina Kyndt<br>6. Reaching beyond crop protection: Synergism between agricultural development and malaria eradication<br>Daniel Strickman, Nick Hamon, Thomas S. Churcher, Ellie Sherrard-Smith and Derek W. Willis<br>7. Discovery and optimization of a novel insecticide, broflanilide<br>T. Nakao, H. Katsuta, M. Nomura, T. Wakita, H. Daido, Y. Kobayashi, A. Kawahara and S. Banba<br>8. Studies on a novel insecticide, fluxametamide<br>T. Mita, Y. Furukawa, M. Iwasa, T. Kikuchi and M. Komoda<br>9. The discovery of isocycloseram: A novel isoxazoline insecticide<br>Jérôme Cassayre, Tomas Smejkal, Judith Blythe, Patrik Hoegger, Peter Renold, Thomas Pitterna, C.S. Prasanna, Helmars Smits, Edouard Godineau, Torsten Luksch, Guillaume Berthon, Girish Rawal, Rupesh Patre, Mukul Lal, Mohamed Boussemghoune, Simonetta Masala, Fabien Barreteau, Michael Flaeschel, Juliane Vogt and Myriem El Qacemi<br>10. Cyclaniliprole: A novel diamide insecticide<br>Masamitsu Tsukamoto, Taku Hamamoto, Masayuki Morita, Kenichi Nakamoto, Akihiro Hisamatsu and Toru Koyanagi<br>11. Optimization of mesoionic pyrido[1,2-a]pyrimidinone insecticides and discovery of 3-biaryl analogs controlling Lepidoptera species<br>Wenming Zhang, Kenneth A. Hughes, Caleb W. Holyoke Jr., My-Hanh T. Tong, George P. Lahm, Thomas F. Pahutski, James Barry, Daniel Cordova, Robert M. Leighty, Ming Xu, Twyla A. Briddell, Stephen F. McCann, Yewande T. Henry and Yuzhong Chen<br>12. Chemistry and biology connected: the development of Inscalis<br>Christopher Koradin, Hartwig Schröder, Kazuhiko Oyama and Satoshi Ōmura<br>13. Spiropidion discovery: Broad spectrum control of sucking insects and mites for multicrop utility<br>M. Muehlebach, J. Schaetzer, A. Buchholz, A.J. Flemming, C.R. Godfrey, E. Godineau, M. Hamer, F. Vock-Hatt, O. Hueter, D.P. Kloer, P. Maienfisch, S. Oliver, F. Perruccio, Thomas Pitterna, C. Popp, R. Senn, R. Slater, Tomas Smejkal, D. Stafford, J. Wenger, L. Wildsmith and W. Zambach<br>14. Discovery of oxazosulfyl: A novel broad-spectrum insecticide<br>Mai Ito, Yoshihiko Nokura, Masaki Takahashi, Hiroji Yamada and Atsushi Iwata<br>15. Synthesis and biological activity of a novel insecticide, benzpyrimoxan<br>Eikoh Satoh, Ryota Kasahara, Kosuke Fukatsu, Takao Aoki, Hiroto Harayama, Tetsuya Murata and Akiyuki Suwa<br>16. Discovery and optimization of silicon-containing complex II acaricides<br>Cong Zhou, Jiagao Cheng, Zhong Li and Peter Maienfisch<br>17. Cycloclavine: A natural product with insecticidal potential<br>Joachim Dickhaut, Andrea Molt and Johannes Röckl<br>18. Photoresponsive pesticidal agents<br>Xusheng Shao<br>19. Discovery and optimization of novel mosquitocidal compounds for the control of anopheline vectors of malaria<br>P. Wege, O. Hueter, M. Hoppé, Peter Maienfisch, R. Nourani and M. Daniels<br>20. Antiparasitic dinitrile compounds for fly control in cattle<br>Nikolas Huwyler, Vincent L. Salgado, Pascal Bindschaedler, Birgit Gockel, Matthias Pohlman, Sebastian Soergel, Douglas D. Anspaugh, Ralph Paulini, Nancy B. Rankl, James S. Hunter III and Charles Meng<br>21. Design, structural derivation, and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives<br>Xiaoyong Xu, Xiulei Chen, Gaolei Wang, Jingwei Zhang, Youxin Xiao, Hongfeng Shen, Yaning Chang, Wei Li, Haowu Jia, Ruifeng Zhang and Xiaofeng Cao<br>22. ADEPIDYN—the first N-methoxy-substituted carboxamide among the succinate dehydrogenase inhibitors<br>Daniel Stierli, Hans Ulrich Haas, Ramya Rajan, Dave Bartlett, Helge Sierotzki, Fredrik Cederbaum, Harald Walter and Clemens Lamberth<br>23. Isoflucypram—the next-generation succinate dehydrogenase inhibitor fungicide<br>Anika Bartholomaeus, Peter Dahmen, Philippe Desbordes, Bernd Essigmann, Stephanie Gary, Oliver Gutbrod, Jochen Kleemann, Peter Lancashire, Michael Maue, Hans-Georg Schwarz and Helen Tinwell<br>24. Discovery and biological profile of inpyrfluxam: A new broad-spectrum succinate dehydrogenase inhibitor fungicide<br>So Kiguchi, Takuya Inoue, Yuichi Matsuzaki, Fukumatsu Iwahashi and Hiroshi Sakaguchi<br>25. Isofetamid: Discovery and optimization of a novel fungicide<br>T. Yoneda, Y. Nakamura, S. Tsukuda, Y. Abe, M. Matsumoto and S. Mitani<br>26. Discovery of the trifluoromethyloxadiazoles—a new class of fungicides with a novel mode-of-action<br>Christian Winter and Marcus Fehr<br>27. The discovery of metyltetraprole: Reconstruction of the quinone outside inhibitor extended pharmacophore to overcome QoI-resistant strains<br>Yuichi Matsuzaki, Yuya Yoshimoto, Sadayuki Arimori and Fukumatsu Iwahashi<br>28. The discovery of florylpicoxamid, a new picolinamide for disease control<br>Kevin G. Meyer, Chenglin Yao, Yu Lu, Karla Bravo-Altamirano, Zachary Buchan, John F. Daeuble, Kyle DeKorver, Jonathan DeLorbe, Ron Heemstra, Jessica Herrick, David Jones, Brian A. Loy, Jared Rigoli, Nick X. Wang, Jeremy Wilmot and David Young<br>29. Discovery and validation of pesticide novel target: take pyruvate kinase as an example<br>Bin Zhao, Lai Chen, Jingao Dong and Zhijin Fan<br>30. Discovery and mode of action of cyclopyrimorate: A new paddy rice herbicide<br>Mamiko Shino, Takahiro Hamada, Yoshio Shigematsu, Kangetsu Hirase, Shinichi Banba, Yoshihisa Tsukamoto and Junji Kadotani<br>31. Toward a mechanistic understanding of IGPD: A potential herbicide target<br>Russell Viner<br>32. Isoxazolopyridines—a novel chemical cluster and a new (?) mode of action for dicot weed control<br>Thomas Seitz, Ruth Campe and Anna Michrowska-Pianowska<br>33. Quinazoline-2,4-dione: A promising scaffold for herbicide discovery<br>Ren-Yu Qu, Jia-Xu Nan, Yao-Chao Yan, Hong-Yan Lin, Wen-Chao Yang and Guang-Fu Yang<br>34. Tirexorâ —design of a new resistance breaking protoporphyrinogen IX oxidase inhibitor<br>Matthias Witschel, Raphael Aponte, Gregory Armel, Peter Bowerman, Thomas Mietzner, Trevor Newton, Aimone Porri, Anja Simon and Thomas Seitz<br>35. Rinskor active herbicide—A new environment-friendly tool for weed management in rice and aquatic environments<br>Rafael Herrera, Monte R. Weimer, Mauricio Morell, Patrick L. Havens, Giovanna Meregalli, Sabitha Papineni, Laura A. Laughlin and Guomin Shan<br>36. Discovery of a novel uracil herbicide by using intermediate derivatization approach<br>Jichun Yang, Aiying Guan, Qiao Wu, Dongliang Cui, Hongjuan Ma and Changling Liu<br>37. Herbicidal activity and application of 1-(furan-2-yl)methylphosphonates as pyruvate dehydrogenase complex inhibitor against broadleaf weeds<br>Hong-Wu He, Yuan Zhou, Hao Peng, Tao Wang, Xiao-song Tan and Jun-Lin Yuan<br>38. Pesticide activities evaluation of b -carboline, dihydro-b -carboline, tetrahydro-b -carboline alkaloids, and their derivatives<br>Hongjian Song, Jingjing Zhang, Yongqiang Li and Qingmin Wang<br>39. Marine natural products and plant virus control<br>Ziwen Wang, Aidang Lu and Qingmin Wang<br>40. Design, synthesis, and biological evaluation of strigolactone derivatives for crop enhancement applications<br>Alain De Mesmaeker, Alexandre Lumbroso, Claudio Screpanti, Katrin Hermann, Mathilde Lachia and Raymonde Fonné-Pfister<br>41. Discovery and optimization of novel plant activators through structure-based virtual screening<br>Qinjie Shi, Yanxia Shi, Kang Chang, Zheng Xu, Pengfei Li, Zhenjiang Zhao, Weiping Zhu, Honglin Li, BaoJu Li, Xuhong Qian and Yufang Xu</p>