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Spinal Cord Injury Pain

Specificaties
Gebonden, blz. | Engels
Elsevier Science | e druk, 2021
ISBN13: 9780128186626
Rubricering
Elsevier Science e druk, 2021 9780128186626
€ 185,80
Levertijd ongeveer 8 werkdagen

Samenvatting

Spinal Cord Injury Pain presents the basis for preclinical and clinical investigations, along with strategies for new approaches in the treatment of central neuropathic pain. Contributors from the private sector and academia provide a comprehensive review of state-of-the-art research in this challenging space. Topics include Epidemiology of Chronic Pain Following SCI, experimental models and mechanisms of chronic pain in SCI, and new targets and technologies. This book serves as a resource for continued translational research that will result in novel approaches and treatments that improve function and quality of life for individuals with CNP/SCI.

Despite a better understanding of the complexity of mechanisms of CNP/SCI, improved medical and surgical management of SCI, and the subsequent acceleration of the identification of new targets and the development of novel analgesics, there is still a great unmet clinical need in the area of CNP following SCI. Hence, this book is a welcomed addition to current research and developments.

Specificaties

ISBN13:9780128186626
Taal:Engels
Bindwijze:Gebonden

Inhoudsopgave

<p>Part I: Approaches to the development of new technologies</p> <p>1. Electrophysiological phenotyping of neuropathic pain following spinal cord injury<br>2. Spinal cord injury pain: A retrospective<br>3. Central neuropathic pain after spinal cord injury: Therapeutic opportunities. A brief history and temporal progression of the pathophysiology from acute trauma to chronic conditions<br>4. Mechanisms of pain below the level of spinal cord injury (SCI)<br>5. Devil’s advocate: Why past and future animal models of neuropathic pain in spinal cord injury are without merit<br>6. Counterpoint: Why animal models are indispensable for translational pain research in spinal cord injury<br>7. Behavioral assays of pain in rodent models of spinal cord injury<br>8. Biomarker signatures for neuropathic pain after SCI<br>9. Decoding nociception in the spinal cord: Computer modeling and machine learning<br>10. EEG biomarkers of pain and applications of machine learning<br>11. Perspectives on preclinical evidence for translation in SCI<br>12. Screening and treatment of neuropathic pain after SCI</p> <p>Part II: Mechanisms of CNP following SCI<br>Section 1: Spinal and supraspinal mechanisms<br>13. Spinal GABA mechanism in neuropathic pain after spinal cord injury<br>14. Glial activation and neuropathic pain<br>15. Mechanisms of CNP following SCI: Chemokines in neuronal-glial cell interaction</p> <p>Section 2: Peripheral mechanisms<br>16. When soft touch hurts: How hugs become painful after spinal cord injury<br>17. Peripheral mechanisms contributing to central neuropathic pain following SCI</p> <p>Section 3: Clinical applications of novel targets and technologies<br>18. Human neural stem cell transplantation for improved recovery after spinal cord injury<br>19. Cell transplantation for reducing neuropathic pain after SCI<br>20. Gene therapy of neuropathic pain after spinal cord injury<br>21. Exercise as a therapeutic intervention for neuropathic pain after spinal cord injury</p>
€ 185,80
Levertijd ongeveer 8 werkdagen

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        Spinal Cord Injury Pain