Modern Approaches in Drug Discovery
Specificaties
Gebonden, blz.
|
Engels
Elsevier Science |
e druk, 2018
ISBN13: 9780128153833
Rubricering
Onderdeel van serie
Methods in Enzymology
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
Modern Approaches in Drug Discovery, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Target Identification and Validation, Cell Painting/High Content Imaging, Target ID using chemical probes, Mining the microbiome for targets, Data driven approaches for diversity and drug-likeness, Affinity-based screening, Fragment screening (X-ray), Array-based approaches, Hit-to-lead: assessment and improvement of drug-like properties, Hit assessment and prioritization, Lead Optimization: fine tuning and risk mitigation, and more.
Specificaties
ISBN13:9780128153833
Taal:Engels
Bindwijze:Gebonden
Uitgever:Elsevier Science
Serie:Methods in Enzymology
Inhoudsopgave
<p>1. Risk Management in Early Discovery Medicinal Chemistry <br>Gurpreet Singh, Jayme L. Dahlin and Michael A. Walters<br>2. Target Identification Using Chemical Probes<br>Moses Moustakim, Suet Ling Felce, Nancy Zaarour, Gillian Farnie, Fiona E. McCann and Paul E. Brennan<br>3. Mining the Microbiome for Drug Targets<br>Qi Wang, Fangming Yang and Huijue Jia<br>4. Screening Library Design<br>Stephanie Kay Ashenden<br>5. Design of a Fragment Screening Library<br>Ashley Taylor, Bradley C. Doak and Martin J. Scanlon<br>6. Genetically Encoded Cyclic Peptide Libraries: From Hit to Lead and Beyond<br>Jacob Valentine and Ali Tavassoli<br>7. A Guide to Run Affinity Screens Using Differential Scanning Fluorimetry and Surface Plasmon Resonance Assays<br>Christian Bergsdorf and Kirk Wright<br>8. Second-Harmonic Generation (SHG) for Conformational Measurements: Assay Development, Optimization, and Screening<br>Tracy A. Young, Ben Moree, Margaret T. Butko, Bason Clancy, Mary Geck Do, Tarun Gheyi, John Strelow, Juan J. Carrillo and Joshua Salafsky<br>9. An Array-Based Ligand Discovery Platform for Proteins With Short Half-Lives<br>Becky S. Leifer, Shelby K. Doyle, André Richters, Helen L. Evans and Angela N. Koehler<br>10. High Content, Phenotypic Assays and Screens for Compounds Modulating Cellular Processes in Primary Neurons<br>Miklos Kepiro, Boglarka H. Varkuti and Ronald L. Davis<br>11. Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening<br>Patrick M. Collins, Alice Douangamath, Romain Talon, Alexandre Dias, Jose Brandao-Neto, Tobias Krojer and Frank von Delft<br>12. Hit-to-Lead: Hit Validation and Assessment<br>Kirk E. Hevener, JinHong Ren, Russell Pesavento, Kiira Ratia, Hyun Lee and Michael E. Johnson<br>13. Knowledge-Based Approaches to Off-Target Screening<br>Daniel R. McMasters</p>