Joao L. de Quevedo,
Joao Luciano de Quevedo,
Joao Quevedo,
Andre Ferrer Carvalho,
Carlos A. Zarate
e.a.
Elsevier Science
e druk, 2019
9780128133330
Neurobiology of Depression
Road to Novel Therapeutics
Specificaties
Paperback, blz.
|
Engels
Elsevier Science |
e druk, 2019
ISBN13: 9780128133330
Rubricering
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD.
Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness.
Specificaties
Inhoudsopgave
1. The Classification of Depression: Embracing Phenotypic Heterogeneity in the Era of the RDoC<br>Elizabeth D. Ballard, Ioline D. Henter and Carlos A. Zarate, Jr.<br>2. The Role of Environmental and Psychosocial Factors in Depression<br>Gordon Parker<br>3. Gene-Environment Interactions and Epigenetic Mechanisms in Depression<br>Magdalene C. Jawahar, Catherine G. Toben and Bernhard T. Baune<br>4. Pathophysiology of Cognitive Impairment in Depression<br>Christopher R. Bowie, Melissa Milanovic and Tanya Tran<br>5. Anhedonia in Depression: Mechanisms, Assessment, and Therapeutics<br>Theodore P. Beauchaine, Daniel N. Klein, Erin Knapton and Aimee Zisner<br>6. The Neurotrophic Hypothesis of Depression Revisited: New Insights and Therapeutic Implications<br>Minal Jaggar, Sashaina E. Fanibunda, Shreya Ghosh, Ronald S. Duman and Vidita A. Vaidya<br>8. Neuro-Immune Interactions in Depression: Mechanisms and Translational Implications<br>Helena M. Abelaira, Ritele H. Silva, Anelise S. Carlessi, João Quevedo and Gislaine Z. Réus<br>9. The Hypothalamic-Pituitary-Adrenal Axis in Depression: Molecular Regulation, Pathophysiological Role, and Translational Implications<br>Theo Rein, Oliver Ambrée, Gabriel R. Fries, Virginie Rappeneau, Ulrike Schmidt and Chadi Touma<br>10. Intracellular Signaling Pathways Implicated in the Pathophysiology of Depression<br>Gislaine Z. Réus, Jaqueline S. Generoso, Ana Lúcia S. Rodrigues and João Quevedo<br>11. The Long-Lasting Neurobiological Scars of Early-Life Stress: Implications for the Neurobiology of Depression<br>Mousa Botros, Gabrielle Hodgins and Charles B. Nemeroff<br>12. Molecular, Cellular, and Circuit Basis of Depression Susceptibility and Resilience<br>Ming-Hu Han, Scott J. Russo and Eric J. Nestler<br>13. More Than a Gut Feeling: Emerging Roles of the Microbiome in the Pathophysiology and Treatment of Depression<br>Jane A. Foster<br>14. Optogenetics: Illuminating the Neural Circuits of Depression<br>Muir J. and Bagot R.C.<br>15. Mitochondrial Dysfunction and Oxidative Stress: Relevance to the Pathophysiology and Treatment of Depression<br>Adrian L. Lopresti<br>16. Obesity and Depression: Shared Pathophysiology and Translational Implications<br>Lison Huet, Ines Delgado, Bruno Aouizerate, Nathalie Castanon and Lucile Capuron<br>17. Depression and Cardiovascular Risk: Epidemiology, Mechanisms, and Implications<br>Jessica Hatch and Benjamin I. Goldstein<br>18. Poststroke Depression: Pathophysiology and Treatment Strategies<br>Yun-Ju Lai and Louise D. McCullough<br>19. Is Depression Associated With Accelerated Aging? Mechanisms and Implications<br>Daniel Lindqvist, Naomi M. Simon and Owen M. Wolkowitz<br>20. Relationship Between Complicated Grief and Depression: Relevance, Etiological Mechanisms, and Implications<br>Nicole J. LeBlanc, Naomi M. Simon, Charles F. Reynolds, III, M. Katherine Shear, Natalia Skritskaya and Sidney Zisook<br>21. A Neural Circuit-Based Model for Depression Anchored in a Synthesis<br>of Insights From Functional Neuroimaging<br>Andrea N. Goldstein-Piekarski and Leanne M. Williams<br>22. Could Depression be Preventable? Evidence and Perspectives<br>Scott B. Patten<br>23. Treating Depression in the Era of Precision Medicine: Challenges and Perspectives<br>Michael Musker and Ma-Li Wong<br>24. Neurobiological Aspects of Functional Recovery in Major Depressive Disorder<br>Trisha Chakrabarty, David Sarfati and Raymond W. Lam<br>25. Diet and Depression: From Epidemiology to Novel Therapeutics<br>Wolfgang Marx, Erin Hoare and Felice Jacka<br>26. Physical Activity and Exercise as a Treatment of Depression: Evidence and Neurobiological Mechanism<br>Brendon Stubbs and Felipe Schuch<br>27. Antidepressants and Suicidality—<br>Controversies and Possible Mechanisms<br>Josef Witt-Doerring and Sanjay Mathew<br>28. Altered GABAergic Function, Cortical Microcircuitry, and Information Processing in Depression<br>Dwight F. Newton, Corey Fee, Yuliya S. Nikolova and Etienne Sibille<br>29. Biomarker-Based Treatment Selection: A Precision Medicine Approach for Depression<br>Jennifer L. Furman and Madhukar H. Trivedi<br>30. Implications of Pharmacogenomics in Depression Pathophysiology and Treatment<br>Forbes M.P., Jaksa P., Eyre H.A. and Bousman C.<br>31. Novel Neuromodulatory Approaches for Depression: Neurobiological Mechanisms<br>Lucia Bulubas, Eva Mezger, Daniel Keeser, Frank Padberg and Andre R. Brunoni<br>32. Electroconvulsive Therapy for Depression: Neurobiological Mechanisms<br>Peter Mulders, Stevie Jaarsveld, Indira Tendolkar and Philip van Eijndhoven<br>33. Deep Brain Stimulation: Mechanisms Underpinning Antidepressant Effects<br>Sonia Torres-Sanchez, Laura Perez-Caballero and Esther Berrocoso<br>34. Novel Therapeutic Targets for Major Depressive Disorder<br>Max A. Lazar and Roger S. McIntyre<br>35. The Search for Rapid Acting Antidepressants: Research Synthesis and Perspectives<br>Gerard Sanacora, Brandon M. Kitay and Samuel T. Wilkinson<br>36. Pediatric Depression<br>Frances Rice and Naomi Warne<br>37. Depression in Women<br>Molly M. Hyer and Gretchen N. Neigh<br>38. Advances in the Neurobiology of Late-Life Depression<br>Breno Satler Diniz and Antonio Lucio Teixeira