Platform Technologies in Drug Discovery and Validation
Specificaties
Gebonden, blz.
|
Engels
Elsevier Science |
e druk, 2017
ISBN13: 9780128130698
Rubricering
Onderdeel van serie
Annual Reports in Medicinal Chemistry
Levertijd ongeveer 8 werkdagen
Samenvatting
Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides.
Specificaties
Inhoudsopgave
<p>1. DNA-Encoded Library Technology: A Brief Guide to Its Evolution and Impact on Drug Discovery<br>Robert A. Goodnow Jr. and Christopher P. Davie<br>2. The Chemistry of Oligonucleotide Delivery<br>David B. Rozema<br>3. CRISPR–Cas9 for Drug Discovery in Oncology<br>Sylvie M. Guichard<br>4. Recent Advances of Microfluidics Technologies in the Field of Medicinal Chemistry<br>László Ürge, Jesus Alcazar, Lena Huck and György Dormán<br>5. High-Throughput Screening<br>Mary Jo Wildey, Anders Haunso, Matthew Tudor, Maria Webb and Jonathan H. Connick<br>6. Kinase-Centric Computational Drug Development<br>Albert J. Kooistra and Andrea Volkamer<br>7. Free Energy Calculation Guided Virtual Screening of Synthetically Feasible Ligand R-Group and Scaffold Modifications: An Emerging Paradigm for Lead Optimization<br>Robert Abel and Sathesh Bhat<br>8. Phenotypic Screening<br>Alleyn T. Plowright and Lauren Drowley<br>9. Targeted Protein Degradation<br>Nello Mainolfi and Tim Rasmusson<br>10. Chemical Biology in Drug Discovery<br>M. Paola Castaldi, Andrea Zuhl, Piero Ricchiuto and J. Adam Hendricks<br>11. Fragment-Based Lead Discovery<br>Ben J. Davis and Stephen D. Roughley<br>12. Antibody-Drug Conjugates<br>Amit Kumar, Jason White, R. James Christie, Nazzareno Dimasi and Changshou Gao<br>13. Antibody-Recruiting Small Molecules: Synthetic Constructs as Immunotherapeutics<br>Patrick J. McEnaney, Christopher G. Parker and Andrew X. Zhang<br>14. A Decade of Deuteration in Medicinal Chemistry<br>Julie F. Liu, Scott L. Harbeson, Christopher L. Brummel, Roger Tung, Robert Silverman and Dario Doller<br>15. From Natural Peptides to Market<br>Claudio D. Schteingart and Jolene L. Lau</p>