1. Directing Biosynthesis: Practical Supply of Natural and Unnatural Cyanobactins<br>Debosmita Sardar, Ma Diarey Tianero and Eric W. Schmidt<br>2. Synthetic Biology Approaches to New Bisindoles<br>Lona M. Alkhalaf, Yi-Ling Du and Katherine S. Ryan<br>3. Enzymatic [4+2] Cycloadditions in the Biosynthesis of Spirotetramates and Spirotetronates<br>Bo Pang, Guannan Zhong, Zhijun Tang and Wen Liu<br>4. Application and Modification of Flavin-Dependent Halogenases<br>Karl-Heinz van Pée, Daniela Milbredt, Eugenio Patallo, Veit Weichold and Maria Gajewi<br>5. Engineering Flavin-Dependent Halogenases<br>James T. Payne, Mary C. Andorfer and Jared C. Lewis<br>6. Heterologous Expression of Fungal Secondary Metabolite Pathways in the Aspergillus Nidulans Host System<br>Johannes W. A. van Dijk and Clay C. C. Wang<br>7. Plug-and-Play Benzylisoquinoline Alkaloid Biosynthetic Gene Discovery in Engineered Yeast<br>Jeremy S. Morris, Mehran Dastmalchi, Jing Li, Limei Chang, Xue Chen, Jillian M. Hagel and Peter J. Facchini<br>8. Optimizing Metabolic Pathways for the Improved Production of Natural Products<br>J. Andrew Jones and Mattheos A. G. Koffas<br>9. Reconstituting Plant Secondary Metabolism in Saccharomyces Cerevisiae for Production of High-Value Benzylisoquinoline Alkaloids<br>Michael E. Pyne, Lauren Narcross, Elena Fossati, Leanne Bourgeois, Euan Burton, Nicholas D. Gold and Vincent J.J. Martin<br>10. Engineering Microbes to Synthesize Plant Isoprenoids<br>Kang Zhou, Steven Edgar and Gregory Stephanopoulos<br>11. Natural Product Biosynthesis in Escherichia Coli: Mentha Monoterpenoids<br>Helen S. Toogood, Shirley Tait, Adrian Jervis, Aisling Ní Cheallaigh, Luke Humphreys, Eriko Takano, John M. Gardiner and Nigel S. Scrutton<br>12. High-Efficiency Genome Editing of Streptomyces Species by an Engineered Crispr/Cas System<br>Yajie Wang, Ryan E. Cobb and Huimin Zhao<br>13. Rapid optimization of engineered metabolic pathways with Serine Integrase Recombinational Assembly (SIRA)<br>Christine Merrick, Caroline Wardrope, Jane Paget, Sean Colloms and Susan Rosser<br>14. Rewiring Riboswitches to Create New Genetic Circuits in Bacteria<br>Christopher J. Robinson, Daniel Medina-Stacey, Ming-Cheng Wu, Helen A. Vincent and Jason Micklefield<br>