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Genomics, Circuits, and Pathways in Clinical Neuropsychiatry

Specificaties
Gebonden, blz. | Engels
Elsevier Science | e druk, 2016
ISBN13: 9780128001059
Rubricering
Elsevier Science e druk, 2016 9780128001059
€ 185,80
Levertijd ongeveer 8 werkdagen

Samenvatting

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders.

Specificaties

ISBN13:9780128001059
Taal:Engels
Bindwijze:Gebonden

Inhoudsopgave

<p>Section 1 The Genome Tools and Methods</p> <p>1. The Newly Emerging View of the Genome</p> <p>Stephan Sanders</p> <p>2. Genetic Epidmeiology</p> <p>Kathleen Ries Merikangas</p> <p>3. Common Variation</p> <p>Mark Daly</p> <p>4. Rare/Structural Variation</p> <p>Daniel Barrera and Jonathan Sebat </p> <p>5. Epigenetics and Epigenomics</p> <p>Eric J. Nestler and John Greally </p> <p>6. Bioinformatics</p> <p>Shaun Purcell</p> <p>7. Imaging Genomics</p> <p>Paul Matthew Thompson</p> <p>8. Stem Cell Technology and Genomics</p> <p>Alysson Renato Muotri</p> <p>9. Association Strategies</p> <p>Benjamin M. Neale</p> <p>10. The promise of Systems Biology</p> <p>Eric Schadt</p> <p>11. Gene networks in neuropsychiatric disease</p> <p>Daniel Geschwind</p> <p>12. Mosaicism</p> <p>Christopher A. Walsh and Saumya Shekhar Jamuar </p> <p>Section 2 A new neuroanatomy</p> <p>13. Mapping the Molecular Landscape of the Human Brain</p> <p>Nenad Sestan</p> <p>14. Studying Circuits</p> <p>Stephan Lammel and Robert Malenka </p> <p>15. Electrophysiological Measurement of Circuits</p> <p>Srikantan S. Nagarajan</p> <p>16. Imaging the Circuitry of the Human Brain</p> <p>Michael Greicius</p> <p>17. Neuroimaging Advances in Alzheimer’s Disease </p> <p>Daniel R. Schonhaut and Gil Rabinovici </p> <p>18. Progressive Supranuclear Palsy and Related Parkinsonian Disorders</p> <p>Jesse A. Brown and William Seeley </p> <p>19. The Anatomy of Basal Ganglia Circuitry of Behavior</p> <p>Nicholas Au Yong, Adrienne M. Keener, Yvette Bordelon, Carlos Portera-Cailliau and Nader Pouratian </p> <p>20. Brainstem Circuitry of Behavior</p> <p>Helmut Heisen</p> <p>21. Apathy – Basal Ganglia, Frontal Circuits</p> <p>Mario F. Mendez</p> <p>22. Emotion Circuitry</p> <p>Robert Wayne Levenson</p> <p>23. Delusions</p> <p>Georges Naasan</p> <p>24. Hallucinations</p> <p>Dennis Velakoulis</p> <p>Section 3 Clinical Phenomenology</p> <p>25. Intro: Risk Overlap Among Disorders</p> <p>Patrick Sullivan</p> <p>26. The conundrum of Clinical Characterization RDOC/ICD-10/DSM</p> <p>Bruce N. Cuthbert</p> <p>27. Schizophrenia</p> <p>Aiden Corvin</p> <p>28. Psychosis</p> <p>Raquel E. Gur and Ruben Gur </p> <p>29. ASD</p> <p>Rebecca Ann Muhle, Stephan Sanders, Hannah Reed and Matthew William State </p> <p>30. Bipolar Disorder</p> <p>Nelson B. Freimer, Carrie E. Bearden and Peter Zandi </p> <p>31. MDD</p> <p>David C. Glahn</p> <p>32. Speech and Language Disorders</p> <p>Marilu Gorno-Tempini</p> <p>33. Molecular Pathways Leading to the Clinical Phenomenology of Frontotemporal Dementia</p> <p>Suzee Eurie Lee and Jennifer S. Yokoyama </p> <p>34. Alzheimer’s</p> <p>Rudy Tanzi</p> <p>35. PTSD</p> <p>Kerry Ressler</p> <p>36. Neurodevelopmental syndromes</p> <p>Elliott Sherr</p> <p>37. Epilepsies</p> <p>Ryan S. Dhindsa, Daniel Lowenstein and David Goldstein </p> <p>38. Substance Abuse</p> <p>Nii Addy</p> <p>39. Neuroimmunology</p> <p>Emmanuel Mignot</p> <p>40. Brain Tumors</p> <p>Vanessa Clark and Murat Günel </p> <p>41. White Matter Disorders</p> <p>Michael David Geschwind and Brianne Magouirk Bettcher </p> <p>42. ALS</p> <p>Elena Ratti and James Berry </p> <p>43. Eating Disorders</p> <p>Cynthia M. Bulik and Garret Stuber </p> <p>Section 4 Clinical Translation and Drug Development</p> <p>44. Pharmacogenomics</p> <p>Roy H. Perlis</p>
€ 185,80
Levertijd ongeveer 8 werkdagen

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        Genomics, Circuits, and Pathways in Clinical Neuropsychiatry