George P. Patrinos,
George Patrinos,
Wilhelm Ansorge
Elsevier Science
e druk, 2005
9780125466615
Molecular Diagnostics
Specificaties
Gebonden, blz.
|
Engels
Elsevier Science |
e druk, 2005
ISBN13: 9780125466615
Rubricering
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
Molecular Diagnostics covers current molecular biological techniques used to identify the underlying molecular defects in inherited disease. Although an increasing number of laboratories, both academic and private are moving in that direction, there are only a few books in the existing literature, and they deal only partly with diagnosis at the molecular level. Each chapter includes the principle and a brief description of the technique, followed by exmples from the authors' own epertise. Contributors are well-known experts in their field, and derive from a variety of disciplines, to ensure breadth and depth of coverage.
Specificaties
Inhoudsopgave
<p>Chapter 1: Molecular Diagnostics: Past, Present, and Future</p> <p>Section I: Molecular Diagnostic Technology</p> <p>Chapter 2: Allele-Specific Mutation Detection by PCR-ARMS and PCR-ASO</p> <p>Chapter 3: Competitive Oligopriming</p> <p>Chapter 4: Oligonucleotide Ligation Assays for the Diagnosis of Inherited Diseases</p> <p>Chapter 5: Enzymatic and Chemical Cleavage Methods to Identify Genetic Variation</p> <p>Chapter 6: Mutation Detection by Single Strand Conformation Polymorphism and Heteroduplex Analysis</p> <p>Chapter 7: Capillary Electrophoresis</p> <p>Chapter 8: Temperature and Denaturing Gradient Gel Electrophoresis</p> <p>Chapter 9: Two-Dimensional Gene Scanning</p> <p>Chapter 10: Real-Time Polymerase Chain Reaction</p> <p>Chapter 11: Pyrosequencing</p> <p>Chapter 12: Molecular Cytogenetics in Molecular Diagnostics</p> <p>Chapter 13: Detection of Genomic Duplications and Deletions</p> <p>Chapter 14: Analysis of Human Splicing Defects Using Hybrid Minigenes</p> <p>Chapter 15: DNA Microarrays and Genetic Testing</p> <p>Chapter 16: Human Genome Microarray in Biomedical Applications</p> <p>Chapter 17: Use of High Throughput Mass Spectrographic Methods to Identify Disease Processes</p> <p>Chapter 18: The Application of Proteomics to Disease Diagnostics</p> <p>Section II: Applications of Molecular Diagnostics and Related Issues</p> <p>Chapter 19: Identification of Genetically Modified Organisms</p> <p>Chapter 20: Pharmacogenetics and Pharmacogenomics: Impact on Drug Discovery and Development</p> <p>Chapter 21: Molecular Diagnostic Applications in Forensic Science</p> <p>Chapter 22: Molecular Diagnostics and Comparative Genomics in Clinical Microbiology</p> <p>Chapter 23: Preimplantation Genetic Diagnosis</p> <p>Chapter 24: Genetic Monitoring of Laboratory Animals</p> <p>Chapter 25: The Use of Locus-Specific Databases in Molecular Diagnostics</p> <p>Chapter 26: Safety Analysis in Retroviral Gene Therapy: Identifying Virus Integration Sites in Gene-Modified Cells</p> <p>Chapter 27: Automated DNA Hybridization and Detection</p> <p>Chapter 28: The Use of Microelectronic-Based Techniques in Molecular Diagnostic Assays</p> <p>Chapter 29: Miniaturization Technologies for Molecular Diagnostics</p> <p>Chapter 30: Human Gene Patents and Genetic Testing</p> <p>Chapter 31: Genetic Counselling and Ethics in Molecular Diagnostics</p> <p>Chapter 32: Genetic Testing and Psychology</p> <p>Chapter 33: Safety in Biomedical and Other Laboratories</p> <p>Chapter 34: Quality Management in the Laboratory</p>