Section I. SIGNALING<br> <br>1. Measurement of insulin proteolysis and assessment of insulin-mediated signaling (events) in (liver) endosomes<br>2. Endosomal sorting and implication for signaling<br>3. TGF-beta in endosomal signaling<br>4. Annexin A6 and endosomal signaling<br>5. PI-3-P in endosomal signaling<br>6.Endosomal signaling and cell migration<br>7. Measuring lipid-ginding effectors in endosomal signaling<br>8. Measuring role for endosomal signaling in tumorigenesis<br>9. Measurement of endosomal signaling in the immune system<br>10. Assessment of the TLR3 pathway in endosomal signaling<br>11. Labeling of platelet-derived growth factor to study its endocytosis and signaling<br>12. Endosomal signaling and oncogenesis<br>13. ROS - Containing endosomal compartments: implications for signaling<br>14. ERBIN in endosomal signaling<br>15. Lipid raft in endosomal signaling<br>16. VEGF-A in endosomal signaling<br>17. Assessment of peptide internalization and endosomal signaling<br>18. Quantitative proteomic analysis of compartmentalized signaling networks<br>19. Death signaling endosomes: sequential activation of Caspase-8, Caspase-9, acid sphingomyelinase and Cathepsin D in internalized TNF-receptosomes<br>20. Deubiquitinases and their emerging roles in cell signaling<br>21. NF-kB-dependent pathway in human keratinocytes<br>22. Endosomal signaling by the G protein coupled PARs<br>23. Investigating signaling consequences of GPCR trafficking in the endocytic pathway<br>24. MICAL-L1 in endosomal signaling