Protein Kinase Inhibitors in Research and Medicine

1. Catalytic Mechanisms and Regulation of Protein Kinases<br>Zhihong Wang and Philip A. Cole.<br>2. A Structural Atlas of Kinases Inhibited by Clinically Approved Drugs<br>Qi Wang, Julie A. Zorn and John Kuriyan.<br>3. Fragment-Based Approaches to the Discovery of Kinase Inhibitors<br>Paul N. Mortenson, Valerio Berdini and Marc O’Reilly.<br>4. Targeting Protein Kinases with Selective and Semi-Promiscuous Covalent Inhibitors<br>Rand M. Miller and Jack Taunton.<br>5. The Resistance Tetrad: Amino Acid Hotspots for Kinome-Wide Exploitation of Drug-resistant Protein Kinase Alleles<br>Veselin I Andreev and Patrick A Eyers<br>6. FLiK: A Direct Binding Assay for the Identification and Kinetic Characterization of Stabilizers of Inactive Kinase Conformations <br>Jeffrey R. Simar and Daniel Rauh<br>7. Discovery of Allosteric Bcr-Abl inhibitors from Phenotypic Screen to Clinical Candidate<br>Nathanael S. Gray and Doriano Fabbro<br>8. The Logic and Design of Analog-Sensitive (AS) Kinases and their Small Molecule Inhibitors<br>Michael S. Lopez, Joseph Kliegman and Kevan M. Shokat