The Mitochondrion in the Germline and Early Development

Section I. The mitochondrion and gametes<br>Chapter 1<br>The role of the mitochondrion in sperm function. Is there a place for oxidative phosphorylation or is this a purely glycolytic process?<br>Chapter 2<br>The role of mitochondrial function in the oocyte and embryo<br>Chapter 3<br>Mitochondrial DNA in the Oocyte and the developing embryo<br><br>Section II. Transmission<br>Chapter 4<br>Mitochondrial DNA and the mammalian oocyte<br>Chapter 5<br>Mitochondrial disease - its impact, aetiology and pathology<br>Chapter 6<br>Cybrid models of mtDNA disease and transmission, from cells to mice<br><br>Section III. The use of ARTs to regulate mtDNA disease.<br>Chapter 7<br>The use of Micromanipulation Methods as a Tool to Prevention of Transmission of Mutated Mitochondrial DNA<br>Chapter 8<br>Difficulties and possible solutions in the Genetic Management of mtDNA disease in the pre-implantation embryo<br><br>Section IV. The effects of invasive ARTs on mtDNA transmission<br>Chapter 9<br>Impact of assisted reproductive techniques: a mitochondrial perspective from the cytoplasmic transplantion <br>Chapter 10<br>Nuclear Transfer – preservation of a nuclear genome at the expense of its associated mtDNA genome(s)