G Protein Pathways, Part A: Receptors

Contributors to Volume 343.<br>Preface.<br>Volume in Series.<br>Section I. G Protein-Coupled Receptors.<br>A. Theoretical Evaluation of Receptor Function:<br>Considerations in the Evaluation of Inverse Agonism and Protean Agonism at G Protein-Coupled Receptors,<br>P. Chidiac.<br>Theoretical Implications of Receptor Coupling to Multiple G Proteins Based on Analysis of a Three-State Model,<br>C. Scaramellini and P. Leff.<br>B. Design and Use of Receptor Ligands:<br>Use of Retinal Analogues for the Study of Visual Pigment Function,<br>R.K. Crouch, V. Kefalov, W. Gartner, and M.C. Cornwall.<br>Design and Synthesis of Peptide Antagonists and Inverse Agonists for G Protein-Coupled Receptors,<br>S.M. Cowell, P.M. Balse-Srinivasan, J.M. Ahn, and V.J. Hruby.<br>Design of Peptide Agonists,<br>V.J. Hruby, R.S. Agnes, C. Cai.<br>Design of Nonpeptides from Peptide Ligands for Peptide Receptors,<br>V.J. Hruby, W. Qiu, T. Okayama, and V.A. Soloshonok.<br>Strategies for Mapping the Binding Site of the Serotonin 5-HT2A Receptor,<br>B.J. Ebersole and S.C. Sealfon.<br>C. Structural Characterization of Receptor Proteins:<br>Use of the Substituted Cysteine Accessibility Method to Study the Structure and Function of G Protein-Coupled Receptors,<br>J.A. Javitch, L. Shi, and G. Liapakis.<br>Mass Spectrometric Analysis of G Protein-Coupled Receptors,<br>D.R. Knapp, R.K. Crouch, L.E. Ball, A.K. Gelasco, and Z. Ablonczy.<br>Probing the Higher Order Structure of G protein-Coupled Receptors Using Tethered Cleavage Methods,<br>A.K. Gelasco, R.K. Crouch, and D.R. Knapp.<br>Use of Fluorescence Spectroscopy to Study Conformational Changes in the b2-Adrenoceptor,<br>B.K. Kobilka and U. Gether.<br>Crystallization of Membrane Protein in Cubo,<br>P. Nollert, J. Navarro, and E.M. Landau.<br>N-Linked Carbohydrates on G Protein-Coupled Receptors: Mapping Sites of Attachment and Determining Functional Roles,<br>D.P. Davis and D.L. Segaloff.<br>Magic Angle Spinning Nuclear Magnetic Resonance of Isotropically Labeled Rhodopsin,<br>M. Eilers, W. Ying, P.J. Reeves, H.G. Khorana, and S.O. Smith.<br>Use of Nuclear Magnetic Resonance to Study the Three-Dimensional Structure of Rhodopsin,<br>P.L. Yeagle and A.D. Albert.<br>D. Design and Use of Engineered Receptor Proteins:<br>Tools for Dissecting Signaling Pathways in Vivo: Receptors Activated Solely by Synthetic Ligands,<br>K. Scearce-Levie, P. Coward, C.H. Redfern, and B.R. Conklin.<br>Analysis of Structure-Function from Expression of G Protein-Coupled Receptor Fragments,<br>S.S. Karnik.<br>Construction and Analysis of Function of G Protein-Coupled Receptor-G Protein Fusion Proteins,<br>G. Milligan.<br>Synthetic Gene Technology: Applications to Ancestral Gene Reconstruction and Structure-Function Studies of Receptors,<br>B.S.W. Chang, M.A. Kazmi, and T.P. Kakmar.<br>Considerations in the Design and Use of Chimeric G Protein-Coupled Receptor,<br>J. Wess.<br>E. Molecular Modeling Studies of Receptor Structure and Function:<br>Strategies for Modeling the Interactions of Transmembrane Helices of G Protein-Coupled Receptors by Geometric Complementarity Using the GRAMM Computer Algorithm,<br>I.A. Vakser and S. Jiang.<br>Three-Dimensional Representation of G Protein-Coupled Receptor Structures and Mechanisms,<br>I. Visiers, J.A. Ballesteros, and H. Weinstein.<br>F. Analysis of Receptor Protein Coupling:<br>Reconstitution of G Protein-Coupled Receptors with Recombinant G Protein a and bg Subunits,<br>W.E. McIntire, C.S. Myung, G. MacCleery, Q. Wang, and J.C. Garrison.<br>Cell-Free Membrane Desensitization Assay for G Protein-Coupled Receptors,<br>M. Hunzicker-Dunn and L. Birnbaumer.<br>Methods to Determine the Constitutive Activity of Histamine H2 Receptors,<br>R. Leurs, M. Hoffman, A.E. Alewijnse, M.J. Smit, and H. Timmerman.<br>Expression of G Protein-Coupled Receptors and G Proteins in Sf9 Cells: Analysis of Coupling by Radioligand Binding,<br>R.T. Windh and D.R. Manning.<br>G Protein-Coupled Receptors and Proliferative Signaling,<br>M.J. Smit, R.A. Bakker, and E.S. Burstein.<br>G. Characterization of Receptor Heterogeneity:<br>Genetic Analysis of G Protein-Coupled Receptor Genes,<br>D.P. Healy.<br>Identification of Adrenergic Receptor Polymorphisms,<br>K.M. Small, D.A. Rathz, and S.B. Liggett.<br>Strategies and Requirements for the Detection of RNA Editing in G Protein Coupled-Receptor RNA,<br>C.M. Niswender.<br>H. The Study of Receptor Trafficking:<br>Fluorescence Microscopy Techniques for the Study of G Protein-Coupled Receptor Trafficking,<br>L. Kallal and J.L. Benovic.<br>Measurement of Receptor Desensitization and Internalization in Interact Cells,<br>R.B. Clark and B.J. Knoll.<br>Morphological and Biochemical Strategies for Monitoring Trafficking of Epitope-Tagged G Protein-Coupled Receptors in Agonist-Naïve and Agonist-Occupied States,<br>M. Wozniak, C. Saunders, N. Schramm, J.R. Keefer, and L.E. Limbird.<br>Section II. Regulators of GPCR Function.<br>A. G Protein-Coupled Receptor Kinases (GRKs):<br>Characterization of G Protein-Coupled Receptor Kinases,<br>A.N. Pronin, R.P. Loudon, and J.L. Benovic.<br>Regulation of G Protein-Coupled Receptor Kinase 2,<br>T. Haga, K. Haga, K. Kameyama, H. Tsuga, and N. Yoshida.<br>Rhodopsin and Its Kinase,<br>I. Sokal, A. Pulvermuller, J. Buczylko, K.P. Hofmann, and K. Palczewski.<br>B. Arrestins and Novel Proteins:<br>Characterization of Arrestin Expression and Function,<br>S.J. Mundell, M.J. Orsini, and J.L. Benovic.<br>Identification of Novel G Protein-Coupled Receptor-Interacting Proteins,<br>R.T. Premont and R.A. Hall.<br>Author Index.<br>Subject Index.