Foreword. <br>Acknowledgments.<br>List of Participants. <br>Session I Signal Transduction in Cancer Cells.<br>Sir Hans A. Krebs centenary lecture: cancer and clinical targeting (G. Weber). <br>Genetic alterations at the nuclear localization signal of the RB2/p130 gene occur in lymphoid tumor but not in osteosarcoma cell lines (N.M. Maraldi). <br>Session II Regulation of Functions through Lipid Signaling.<br>An expanded view of inositol signaling (J.D. York). <br>Regulation of protein synthesis in the heart (F.H. Pham). <br>Session III Regulation through Protein Kinases.<br>Spontaneous occurrence of an inhibitor of protein kinase localization in a thyroid cancer cell line: role in thyroid tumorigenesis (D. Mochly-Rosen). <br>Regulation and role of the atypical PKC isoforms in cell survival during tumor transformation (J. Moscat). <br>The protein kinase activity modulation sites: mechanisms for cellular regulation - targets for the therapeutic intervention (R.A. Engh, D. Bossemeyer). <br>Session IV Enzymic Regulation and Pharmacology.<br>Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil (M.R. Johnson, R.B. Diasio). <br>Regulation of retinoic acid metabolism (M. Petkovich). <br>Session V Drug Targeting and Resistance.<br>Comparison of the properties of human breast cancer cells: MCF-7 and MCF-7 cells selected for resistance to etoposide (J.G. Cory). <br>The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting (H. Maeda). <br>Session VI mRNA Stability and Regulation of Apoptosis.<br>Adipocyte expression of a neuronal RNA binding protein (C. Qi, P.H. Pekala). <br>Apoptosis signaling pathways mediated by cyclooxygenase-2 inhibitors in prostate cancer cells (A.J. Johnson, C.-S. Chen). <br>Novel procaspase-3 activating cascade mediated by lysoapoptases and its biological significances in apoptosis (N. Katunuma). <br>Session VII Degradative Enzymes and Transformation.<br>Effect of malignant transformation on lactate levels of human mammary epithelial cells (E.O. Aboagye). <br>The RAS-RAF relationship: an unfinished puzzle (E. Kerkhoff, U. Rapp). <br>Session VIII Transformation and Kinases.<br>Control of pyruvate dehydrogenase kinase gene expression (R.A. Harris). <br>Synergistic effects of PI3K/AKT on abrogation of cytokine-dependency induced by oncogenic RAF (J.A. McCubrey). <br>Session IX Enzyme Regulation and Disease.<br>Pathogenesis of adult-onset type II citrullinemia caused by deficiency of citrin, a mitochondrial solute carrier protein: tissue and subcellular localization of citrin (M. Iijima, T. Saheki). <br>Human heparanase: a molecular determinant of brain metastasis (D. Marchetti). <br>Session X Special Symposium Lecture: Lucio Cocco.<br>Nuclear inositol lipid signaling (L. Cocco).<br>Author Index.<br>Subject Index. <br>
